PRME Prime Medicine, Inc.

QT54

Latest market price

4.44

-0.28-5.93%

Overview Short InterestFilings

PRMEQT54Prime Medicine, Inc.·NASDAQ

Overview Short InterestFilings

4.44-5.93%

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Signal & projected range

Short-squeeze setupHistorical pattern — not a prediction

Recent priceDays this stock last showed the setupRange of past outcomes (±1σ)

Horizon

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Over the next 20 trading days, similar setups historically landed in a measured range of outcomes. Unlock with Premium to see the median return, the typical range, and how often they were positive. This is the historical range of outcomes — not a prediction of this stock’s price.

Ranges describe how this exact setup resolved in the past — derived from thousands of historical occurrences across QuoTrend’s coverage since 2006, survivorship-corrected to include companies that later delisted. The band is the typical spread (±1σ) of those outcomes, not a forecast; the central value is their average move. Fewer matching cases over longer horizons widen the band and lower its reliability. Backtested results are hypothetical, based on historical data, and do not represent actual trading. Past performance does not guarantee or predict future results. QuoTrend is an educational research tool, not investment advice. Markets involve risk, including loss of principal.

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QURE-7.49%$22.97 RARE+1.24%$16.30 NUVB-3.57%$4.59 TRAX-0.07%$45.05 NTLA-6.50%$11.66 ABSI-12.94%$9.69 URGN+5.01%$34.36 MAZE-3.53%$30.37

Snapshot

Index	—	P/E	—	EPS (ttm)	-1.10	Insider Own	39.55%	Shs Outstand	181.38M	Perf Week	22.99%

Market Cap	805.31M	Forward P/E	—	EPS next Y	-0.92	Insider Trans	0.00%	Shs Float	59.42M	Perf Month	48.99%

Enterprise Value	814.31M	PEG	—	EPS next Q	-0.24			Short Float	55.32%	Perf Quarter	48.99%

Income	-188.00M	P/S	—	EPS this Y	—			Short Ratio	9.51	Perf Half Y	27.95%

Sales	4.00M	P/B	20.14	EPS next Y	—	ROA	-75.45%	Short Interest	32.87M	Perf YTD	27.95%

Book/sh	0.22	P/C	8.48	EPS next 5Y	—	ROE	-188.27%	52W High	5.91 -24.87%	Perf Year	2.07%

Cash/sh	0.52	P/FCF	—	EPS past 3/5Y	—	ROIC	-86.83%	52W Low	2.67 66.29%	Perf 3Y	-25.81%

Dividend Est.	—	EV/EBITDA	—	Sales past 3/5Y	— 0.00%	Gross Margin	-1025.61%	Volatility	17.51% 12.15%	Perf 5Y	—

Dividend TTM	—	EV/Sales	—	EPS Y/Y TTM	—	Oper. Margin	-4824.94%	ATR (14)	0.46	Perf 10Y	—

Dividend Ex-Date	Mar 22, 2018	Quick Ratio	3.05	Sales Y/Y TTM	0.00%	Profit Margin	-4613.11%	RSI (14)	57.21	Recom	2.30

Dividend Gr. 3/5Y	—	Current Ratio	3.05	EPS Q/Q	41.46%	SMA20	12.70%	Beta	2.44	Target Price	7.50

Payout	0.00%	Debt/Eq	2.60	Sales Q/Q	0.00%	SMA50	24.75%	Rel Volume	1.01	Prev Close	4.72

Employees	146	LT Debt/Eq	2.60	Earnings	Nov 06	SMA200	27.00%	Avg Volume	4.07M	Price	4.44

IPO Date	Oct 20, 2022	Option/Short	Yes / Yes	EPS/Sales Surpr.	6.70% -48.74%	Net Debt/EBITDA	—	Volume	4,122,737	Change	-5.93%

Analyst Ratings

Date	Action	Analyst	Rating	Target
Aug-25-26	Reiterated	Chardan Capital	Buy	$7.00
Jun-29-26	Reiterated	New Street		$8.00
Jun-29-26	Upgrade	HC Wainwright & Co.	Neutral → Buy
Jun-22-26	Reiterated	Goldman Sachs		$6.00
May-27-25	Downgrade	Citigroup	Buy → Neutral
May-20-25	Downgrade	JP Morgan	Overweight → Neutral
May-20-25	Downgrade	HC Wainwright & Co.	Buy → Neutral
May-16-24	Upgrade	Citigroup	Neutral → Buy
May-07-24	Reiterated	Jefferies		$15
Apr-02-24	Initiated	Wedbush	Buy	$12

Latest News· Times ET

Oct-29-26

Oct-29-2604:46AM

Prime Medicine, Inc. (PRME) Surges 23.2%: Is This an Indication of Further Gains?zacks.com

Oct-28-26

Oct-28-2603:34PM

PRME, BEAM, EDIT, NTLA, CRSP Stocks Gain As FDA Signals Faster Route For Patient-Specific Gene EditsYahoo

Oct-15-26

Oct-15-2607:56PM

Prime Drink Group Announces Subscription Receipt Financing and Closing of Second Tranche of Private Placement of Unitsbusinesswire.com

Oct-12-26

Oct-12-2601:25PM

Prime Medicine Stock Rallies Nearly 26% in a Month: Here's Whyzacks.com

Oct-11-26

Oct-11-2611:54AM

Leading Indicators For The October Breakout Cycleseekingalpha.com

Oct-06-26

Oct-06-2605:59AM

Apogee Enterprises Posts Upbeat Q2 Earnings, Joins Constellation Energy, Freshworks And Other Big Stocks Moving Higher On TuesdayBenzinga

Oct-05-26

Oct-05-2608:00AM

Prime Medicine Announces First Patient Dosed in Global Phase 1/2 Clinical Trial of PM577a for H1069Q-Mutated Wilson Diseaseglobenewswire.com

Sep-29-26

Sep-29-2609:00AM

Temporary Weakness in Intellia Stock Seems Like a Buying OpportunityYahoo

Sep-25-26

Sep-25-2601:56PM

Prime Medicine Gets FDA Green Light for Gene Editing Studybenzinga.com

Sep-24-26

Sep-24-2604:01PM

Prime Medicine Announces U.S. FDA Clearance of Investigational New Drug Application for PM647 in Alpha-1 Antitrypsin Deficiencyglobenewswire.com

10:59AM

Crispr Therapeutics: Why AI Giant Anthropic's Discovery Has Rocked Gene EditingSeekingAlpha

Sep-17-26

Sep-17-2604:09PM

Gene-Editing Powerhouse And Its Rivals Surge Toward A BreakoutYahoo

Sep-16-26

Sep-16-2606:01PM

Prime Medicine, Inc. (PRME) Presents at Morgan Stanley 24th Annual Global Healthcare Conference Transcriptseekingalpha.com

Sep-10-26

Sep-10-2605:30PM

Prime Drink Group Provides Bi-Weekly MCTO Status Reportglobenewswire.com

Sep-03-26

Sep-03-2608:00AM

Prime Medicine to Participate in Upcoming Investor Conferencesglobenewswire.com

Company

Prime Medicine, Inc. operates as a biotechnology firm, dedicated to delivering genetic therapies for various diseases by strategically employing advanced gene editing technology. Central to their platform is the "Prime Editor" system, which combines a unique Prime Editor protein—a hybrid composed of a Cas protein and a reverse transcriptase enzyme—with a specialized pegRNA molecule. This pegRNA plays a crucial role by both guiding the Prime Editor to a precise location within the genome and providing the essential template for introducing the desired modification to the target DNA sequence. The company, founded in 2019, maintains its headquarters in Cambridge, Massachusetts.

Ownership

Per-holder 13F data hasn't been ingested for this ticker yet.

Financial Statements

DataTimeframe

Line Item (USD, M)	TTM —	FY 2025 12/31/2025	FY 2024 12/31/2024	FY 2023 12/31/2023	FY 2022 12/31/2022	FY 2021 12/31/2021	FY 2020 12/31/2020	FY 2019 12/31/2019
Total Revenue	4	5	3	0	—	—	—	—
Cost of Goods Sold Incl. D&A	46	7	0	0	—	—	—	—
Gross Profit	-42	-3	3	0	—	—	—	—
Selling, General and Administrative Excl. Other	54	52	50	43	—	—	—	—
Research and Development	146	161	155	148	—	—	—	—
Other Operating Expense	-46	-7	0	14	—	—	—	—
Operating Income	-197	-208	-202	-205	—	—	—	—
Interest Expense	0	0	0	0	—	—	—	—
Unusual Expense	—	—	—	—	—	—	—	—
Non-Operating Income (Expense)	9	7	7	6	—	—	—	—
Net Income Before Taxes	-188	-201	-196	-198	—	—	—	—
Income Taxes	0	0	0	0	—	—	—	—
Consolidated Net Income	-188	-201	-196	-198	—	—	—	—
Net Income From Continuing Operations	-188	-201	-196	-198	—	—	—	—
Net Income	-188	-201	-196	-198	—	—	—	—
EPS (Recurring)	-1.10	-1.35	-1.65	-2.18	—	—	—	—
EPS (Basic, Before Extraordinaries)	-1.10	-1.35	-1.65	-2.18	—	—	—	—
EPS (Diluted)	-1.10	-1.35	-1.65	-2.18	—	—	—	—
EBITDA	-180	-196	-190	-187	—	—	—	—
Other After Tax Adjustments	—	—	—	—	—	—	—	—
Stock Option Compensation Expense	—	—	—	—	—	—	—	—
Price To Earnings Ratio	—	—	—	—	—	—	—	—
Price To Sales Ratio	196.47	103.41	115.83	—	—	—	—	—
Gross Margin	-1,050.00	-60.00	100.00	—	—	—	—	—
Operating Margin	-4,925.00	-4,160.00	-6,733.33	—	—	—	—	—
Net Margin	-4,700.00	-4,020.00	-6,533.33	—	—	—	—	—
Shares Outstanding	177	149	119	91	—	—	—	—
Market Capitalization	786	517	347	806	—	—	—	—
Operating Lease Expense	—	—	—	—	—	—	—	—

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Insider Trading Volume

Insider Trading

Insider	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
GV 2021 GP, L.L.C.	10% Owner	Aug 01 '25	Buy	3.30	1,500,000	4,950,000	3,262,440	Aug 05
ARCH Venture Partners X, LLC	10% Owner	Aug 01 '25	Buy	3.30	3,030,300	9,999,990	6,230,300	Aug 01
NELSEN ROBERT	Director, 10% Owner	Aug 01 '25	Buy	3.30	3,030,300	9,999,990	6,230,300	Aug 01
ARCH Venture Partners XII, LLC	10% Owner	Aug 01 '25	Buy	3.30	3,030,300	9,999,990	6,230,300	Aug 01
Liu David R.	10% Owner	Jun 30 '25	Buy	2.52	21,000	52,830	20,240,945	Jul 01
Liu David R.	10% Owner	Jun 23 '25	Buy	2.16	21,000	45,402	20,219,945	Jun 23
Liu David R.	10% Owner	Jun 16 '25	Buy	1.49	21,000	31,196	20,198,945	Jun 16
Liu David R.	10% Owner	Jun 11 '25	Buy	1.60	21,000	33,590	20,177,945	Jun 12
LEE ANN L.	Chief Technical Officer	May 21 '25	Buy	1.13	100,000	113,000	100,000	May 22
Reine Allan	Chief Executive Officer	May 21 '25	Buy	1.18	125,000	147,150	125,000	May 22
Brudnick Richard	Chief Business Officer	May 20 '25	Buy	1.19	20,000	23,790	20,000	May 22
NELSEN ROBERT	Director, 10% Owner	Feb 15 '24	Buy	6.25	3,200,000	20,000,000	3,200,000	Feb 20
ARCH Venture Partners XII, LLC	10% Owner	Feb 15 '24	Buy	6.25	3,200,000	20,000,000	3,200,000	Feb 20
ARCH Venture Partners X, LLC	10% Owner	Feb 15 '24	Buy	6.25	3,200,000	20,000,000	3,200,000	Feb 20
GV 2019 GP, L.L.C.	10% Owner	Jun 21 '23	Sale	14.97	19,003	284,496	0	Jun 22

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QuoTrend signals describe historical patterns and statistics — educational information, not investment advice or a recommendation to buy or sell. Past performance doesn’t guarantee future results. Every figure traces to QuoTrend data. Historical patterns — not a prediction or advice.