PRAX — Praxis Precision Medicines, Inc. stock price, charts and financials
QT91Praxis Precision Medicines, Inc.Praxis Precision Medicines, Inc. (NASDAQ: PRAX) is a Healthcare company in the Biotechnology industry. QuoTrend tracks its price, financials, earnings, analyst ratings and insider trades.
| Index | - | P/E | - | EPS (ttm) | - | Insider Own | - | Shs Outstand | 27.88M | Perf Week | 4.82% |
| Market Cap | 8.64B | Forward P/E | - | EPS next Y | -10.40 | Insider Trans | -0.05% | Shs Float | 26.12M | Perf Month | -1.09% |
| Enterprise Value | 8.29B | PEG | - | EPS next Q | - | Inst Own | - | Short Float | 14.41% | Perf Quarter | -8.16% |
| Income | -303.00M | P/S | 0.00 | EPS this Y | - | Inst Trans | - | Short Ratio | 7.54 | Perf Half Y | 0.31% |
| Sales | 0.00 | P/B | 20.63 | EPS next Y | 31.89% | ROA | -22.36% | Short Interest | 3.76M | Perf YTD | 5.20% |
| Book/sh | 15.03 | P/C | 24.56 | EPS next 5Y | - | ROE | -43.02% | 52W High | 366.51 -15.40% | Perf Year | 473.25% |
| Cash/sh | 12.63 | P/FCF | - | EPS past 3/5Y | - | ROIC | -25.32% | 52W Low | 37.19 733.75% | Perf 3Y | 2009.32% |
| Dividend Est. | - | EV/EBITDA | - | Sales past 3/5Y | - | Gross Margin | 0.00% | Volatility | 5.13% 5.61% | Perf 5Y | 31.66% |
| Dividend TTM | - | EV/Sales | 0.00 | EPS Y/Y TTM | -30.95% | Oper. Margin | 0.00% | ATR (14) | 18.07 | Perf 10Y | - |
| Dividend Ex-Date | - | Quick Ratio | 15.88 | Sales Y/Y TTM | - | Profit Margin | 0.00% | RSI (14) | 49.65 | Recom | 2.31 |
| Dividend Gr. 3/5Y | - | Current Ratio | 15.88 | EPS Q/Q | 2.74% | SMA20 | -1.41% | Beta | 2.74 | Target Price | 578.86 |
| Payout | 0.00% | Debt/Eq | 0.00 | Sales Q/Q | - | SMA50 | 1.32% | Rel Volume | 0.68 | Prev Close | 305.51 |
| Employees | 168 | LT Debt/Eq | 0.01 | Earnings | Aug 06 | SMA200 | 8.05% | Avg Volume | 482.27K | Price | 310.07 |
| IPO Date | Oct 16, 2020 | Option/Short | Yes / Yes | EPS/Sales Surpr. | 10.85% - | Net Debt/EBITDA | 1.64 | Volume | 326,888 | Change | 1.49% |
| Date | Action | Analyst | Rating | Target |
|---|---|---|---|---|
| Jul-13-26 | Initiated | Goldman Sachs | Buy | $447 |
| Jun-29-26 | Reiterated | Needham | Buy | $510 → $575 |
| Jun-17-26 | Initiated | RBC Capital | Outperform | $449 |
| Jun-02-26 | Reiterated | Robert W. Baird | $433 → $400 | |
| Jun-02-26 | Reiterated | BTIG | Buy | $843 → $810 |
| Jun-02-26 | Reiterated | HC Wainwright & Co. | Buy | $1201 |
| Jun-02-26 | Reiterated | Truist Securities | Buy | $715 → $616 |
| Jun-02-26 | Reiterated | Deutsche Bank | Buy | $420 → $374 |
| Jun-02-26 | Reiterated | Wedbush | Underperform | $166 → $162 |
| Jun-02-26 | Reiterated | Oppenheimer | Outperform | $750 → $650 |
Praxis Precision Medicines, Inc. is a biopharmaceutical firm operating at the clinical stage, dedicated to creating innovative treatments for central nervous system (CNS) conditions that stem from an imbalance in neuronal activity. The company's primary investigational compounds currently undergoing evaluation include: PRAX-114, an extrasynaptic-preferring positive allosteric modulator of the GABAA receptor, which is currently in Phase IIa clinical trials for addressing both major depressive disorder and perimenopausal depression. Additionally, PRAX-944, a small molecule designed to selectively inhibit T-type calcium channels, is also progressing through Phase IIa clinical trials to manage essential tremor. Beyond these, Praxis is also advancing a pipeline of other promising drug candidates, such as: PRAX-562, a persistent sodium current blocker, undergoing Phase I clinical evaluation for treating severe pediatric epilepsy and adult cephalgia (headaches). PRAX-222, an antisense oligonucleotide (ASO) aimed at individuals suffering from gain-of-function (GOF) SCN2A epilepsy. And a program targeting KCNT1 for the treatment of KCNT1 GOF epilepsy. To further its research and development efforts, Praxis maintains several strategic alliances. These include a cooperation and licensing arrangement with RogCon Inc.; a licensing deal with Purdue Neuroscience Company; a comprehensive research collaboration, option, and license agreement with Ionis Pharmaceuticals, Inc.; and a collaborative project with The Florey Institute focused on the creation of three new antisense oligonucleotides (ASOs). Established in 2015, the company's headquarters are situated in Boston, Massachusetts.
Per-holder 13F data hasn't been ingested for this ticker yet.
| Line Item (USD, M) | FY 2025 12/31/2025 | FY 2024 12/31/2024 | FY 2023 12/31/2023 | FY 2022 12/31/2022 | FY 2021 12/31/2021 | FY 2020 12/31/2020 | FY 2019 12/31/2019 | FY 2018 12/31/2018 | |
|---|---|---|---|---|---|---|---|---|---|
| Total Revenue | 0 | 9 | 2 | 0 | 0 | 0 | 0 | 0 | |
| Cost of Goods Sold Incl. D&A | 0 | 152 | 87 | 154 | 0 | 0 | 1 | 0 | |
| Gross Profit | 0 | -144 | -84 | -154 | 0 | 0 | -1 | 0 | |
| Selling, General and Administrative Excl. Other | 59 | 56 | 42 | 60 | 47 | 17 | 6 | 4 | |
| Research and Development | 267 | 152 | 87 | 155 | 120 | 45 | 30 | 19 | |
| Other Operating Expense | 0 | -152 | -87 | -154 | 0 | 0 | 0 | 0 | |
| Operating Income | -326 | -200 | -126 | -215 | -167 | -62 | -36 | -23 | |
| Interest Expense | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Unusual Expense | — | — | — | — | — | — | — | — | |
| Non-Operating Income (Expense) | 23 | 17 | 3 | 1 | 0 | 0 | 0 | -4 | |
| Net Income Before Taxes | -303 | -183 | -123 | -214 | -167 | -62 | -36 | -26 | |
| Income Taxes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Consolidated Net Income | -303 | -183 | -123 | -214 | -167 | -62 | -36 | -27 | |
| Net Income From Continuing Operations | -303 | -183 | -123 | -214 | -167 | -62 | -36 | -27 | |
| Net Income | -303 | -183 | -123 | -214 | -167 | -62 | -36 | -27 | |
| EPS (Recurring) | -13.48 | -10.21 | -18.69 | -69.33 | -58.96 | -103.61 | -348.24 | -306.73 | |
| EPS (Basic, Before Extraordinaries) | -13.48 | -10.21 | -18.69 | -69.33 | -58.96 | -103.61 | -348.24 | -306.73 | |
| EPS (Diluted) | -13.48 | -10.21 | -18.69 | -69.33 | -58.96 | -103.61 | -348.24 | -306.73 | |
| EBITDA | -303 | -182 | -123 | -214 | -167 | -62 | -35 | -26 | |
| Other After Tax Adjustments | — | — | — | — | — | — | — | — | |
| Stock Option Compensation Expense | — | — | — | — | — | — | — | — | |
| Price To Earnings Ratio | — | — | — | — | — | — | — | — | |
| Price To Sales Ratio | — | 153.92 | 77.98 | — | — | — | — | — | |
| Gross Margin | — | -1,600.00 | -4,200.00 | — | — | — | — | — | |
| Operating Margin | — | -2,222.22 | -6,300.00 | — | — | — | — | — | |
| Net Margin | — | -2,033.33 | -6,150.00 | — | — | — | — | — | |
| Shares Outstanding | 23 | 18 | 7 | 3 | 3 | 1 | 0 | 0 | |
| Market Capitalization | 6,779 | 1,385 | 156 | 107 | 887 | 825 | — | — | |
| Operating Lease Expense | — | — | — | — | — | — | — | — |
| Insider | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|
| DeSimone Jill | Director | Jun 24 '26 | Option Exercise | 71.20 | 11,600 | 825,954 | 13,937 | Jun 26 |
| DeSimone Jill | Director | Jun 24 '26 | Sale | 311.32 | 11,600 | 3,611,334 | 2,337 | Jun 26 |
| Nemiroff Alex | General Counsel and Secretary | Nov 20 '25 | Sale | 193.09 | 25,130 | 4,852,256 | 20,832 | Nov 21 |
| Nemiroff Alex | General Counsel and Secretary | Nov 20 '25 | Option Exercise | 73.76 | 25,130 | 1,853,532 | 45,962 | Nov 21 |
| Mastrocola Lauren | Principal Accounting Officer | Nov 20 '25 | Option Exercise | 61.12 | 13,600 | 831,258 | 24,042 | Nov 21 |
| Mastrocola Lauren | Principal Accounting Officer | Nov 20 '25 | Sale | 192.08 | 13,600 | 2,612,244 | 10,442 | Nov 21 |
| Adage Capital Management, L.P. | 10% Owner | Oct 16 '25 | Sale | 105.76 | 313,910 | 33,198,124 | 2,060,175 | Oct 17 |
| MITCHELL DEAN J | Director | Sep 24 '25 | Option Exercise | 39.51 | 12,251 | 483,992 | 17,251 | Sep 25 |
| Mastrocola Lauren | Principal Accounting Officer | Nov 14 '24 | Sale | 81.78 | 5,188 | 424,318 | 5,613 | Nov 15 |
| Nemiroff Alex | General Counsel and Secretary | Nov 14 '24 | Option Exercise | 56.94 | 7,583 | 431,776 | 18,540 | Nov 15 |
| Nemiroff Alex | General Counsel and Secretary | Nov 14 '24 | Sale | 80.20 | 8,239 | 660,827 | 10,301 | Nov 15 |
| Mastrocola Lauren | Principal Accounting Officer | Nov 14 '24 | Option Exercise | 56.94 | 4,374 | 249,056 | 10,801 | Nov 15 |
| DeSimone Jill | Director | Oct 05 '23 | Buy | 1.75 | 14,500 | 25,375 | 14,500 | Oct 10 |
| Souza Marcio | Chief Executive Officer | Jun 27 '23 | Buy | 1.06 | 10,000 | 10,587 | 45,002 | Jun 27 |
| Kelly Timothy Edwin | Chief Financial Officer | Mar 24 '23 | Buy | 0.87 | 16,000 | 13,996 | 46,416 | Apr 06 |