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| Ticker | Owner | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Jun 26 '25 | Option Exercise | 0.00 | 10,173,001 | 1,018 | 22,970,388 | Jun 27 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | May 19 '25 | Buy | 11.78 | 5,919 | 69,738 | 17,883,908 | May 19 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | May 15 '25 | Buy | 11.43 | 49,502 | 565,847 | 17,877,989 | May 19 12:00 AM |
| PRTA | EcoR1 Capital, LLC | 10% Owner | May 06 '25 | Sale | 7.64 | 1,984,053 | 15,164,712 | 5,304,596 | May 06 12:00 AM |
| PRTA | EcoR1 Capital, LLC | 10% Owner | May 05 '25 | Sale | 8.11 | 977,693 | 7,930,166 | 7,288,649 | May 06 12:00 AM |
| PRTA | EcoR1 Capital, LLC | 10% Owner | May 02 '25 | Sale | 8.36 | 3,317,938 | 27,744,929 | 8,266,342 | May 06 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Apr 17 '25 | Buy | 11.52 | 54,760 | 630,819 | 17,828,487 | Apr 18 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Apr 16 '25 | Buy | 11.16 | 73,953 | 825,589 | 17,773,727 | Apr 18 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Apr 04 '25 | Buy | 11.17 | 196,438 | 2,193,800 | 17,699,774 | Apr 07 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Apr 03 '25 | Buy | 11.84 | 120,770 | 1,430,170 | 17,503,336 | Apr 07 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Apr 02 '25 | Buy | 11.85 | 74,360 | 881,017 | 17,382,566 | Apr 02 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Apr 01 '25 | Buy | 11.60 | 48,658 | 564,647 | 17,308,206 | Apr 02 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Mar 31 '25 | Buy | 11.75 | 4,397 | 51,658 | 17,259,548 | Apr 02 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Mar 26 '25 | Buy | 12.24 | 43,848 | 536,857 | 17,255,151 | Mar 27 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Mar 25 '25 | Buy | 12.91 | 53,501 | 690,452 | 17,211,303 | Mar 27 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Mar 24 '25 | Buy | 13.08 | 22,689 | 296,847 | 17,157,802 | Mar 24 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Mar 21 '25 | Buy | 12.78 | 31,033 | 396,518 | 17,135,113 | Mar 24 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Mar 20 '25 | Buy | 12.93 | 73,476 | 949,883 | 17,104,080 | Mar 24 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Mar 19 '25 | Buy | 12.64 | 58,306 | 737,233 | 17,030,604 | Mar 19 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Mar 18 '25 | Buy | 12.65 | 113,880 | 1,440,855 | 16,972,298 | Mar 19 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Mar 17 '25 | Buy | 12.23 | 56,277 | 688,465 | 16,858,418 | Mar 19 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Mar 13 '25 | Buy | 12.48 | 468,356 | 5,847,237 | 16,802,141 | Mar 13 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Mar 12 '25 | Buy | 12.25 | 292,934 | 3,587,826 | 16,333,785 | Mar 13 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Mar 11 '25 | Buy | 11.49 | 320,690 | 3,685,851 | 16,040,851 | Mar 13 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Jan 17 '25 | Buy | 13.87 | 19,748 | 273,998 | 15,720,161 | Jan 21 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Jan 16 '25 | Buy | 13.88 | 121,681 | 1,689,541 | 15,700,413 | Jan 21 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Jan 15 '25 | Buy | 14.01 | 39,029 | 546,671 | 15,578,732 | Jan 15 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Jan 14 '25 | Buy | 13.56 | 54,500 | 739,265 | 15,539,703 | Jan 15 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Jan 13 '25 | Buy | 13.39 | 74,125 | 992,875 | 15,485,203 | Jan 15 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Jan 10 '25 | Buy | 13.13 | 204,098 | 2,678,990 | 15,411,078 | Jan 10 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Jan 08 '25 | Buy | 14.07 | 21,021 | 295,829 | 15,206,980 | Jan 10 12:00 AM |
| ANAB | EcoR1 Capital, LLC | director, 10 percent owner: | Jan 02 '25 | Buy | 12.95 | 6,646 | 86,070 | 7,880,094 | Jan 02 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Jan 02 '25 | Buy | 14.78 | 157,880 | 2,333,403 | 15,185,959 | Jan 02 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Dec 31 '24 | Buy | 14.57 | 146,501 | 2,134,446 | 15,028,079 | Jan 02 12:00 AM |
| ANAB | EcoR1 Capital, LLC | director, 10 percent owner: | Dec 31 '24 | Buy | 12.93 | 13,268 | 171,513 | 7,873,448 | Jan 02 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Dec 30 '24 | Buy | 14.47 | 58,988 | 853,326 | 14,881,578 | Jan 02 12:00 AM |
| ANAB | EcoR1 Capital, LLC | director, 10 percent owner: | Dec 30 '24 | Buy | 12.92 | 65,184 | 842,060 | 7,860,180 | Jan 02 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Dec 27 '24 | Buy | 14.49 | 101,659 | 1,473,181 | 14,822,590 | Dec 27 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Dec 26 '24 | Buy | 14.38 | 16,692 | 240,038 | 14,720,931 | Dec 27 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Dec 24 '24 | Buy | 14.12 | 11,958 | 168,896 | 14,704,239 | Dec 27 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Dec 23 '24 | Buy | 14.25 | 251,502 | 3,584,105 | 14,692,281 | Dec 26 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Dec 20 '24 | Buy | 14.08 | 704,488 | 9,917,500 | 14,440,779 | Dec 26 12:00 AM |
| ZYME | EcoR1 Capital, LLC | director, 10 percent owner: | Dec 19 '24 | Buy | 13.53 | 298,818 | 4,042,679 | 13,736,291 | Dec 26 12:00 AM |
| TNGX | EcoR1 Capital, LLC | 10% Owner | Nov 07 '24 | Sale | 2.94 | 1,205,442 | 3,539,720 | 10,630,736 | Nov 08 12:00 AM |
| TNGX | EcoR1 Capital, LLC | 10% Owner | Nov 06 '24 | Sale | 3.28 | 1,494,558 | 4,896,023 | 11,836,178 | Nov 08 12:00 AM |
| ANAB | EcoR1 Capital, LLC | 10% Owner | Aug 14 '24 | Buy | 36.50 | 273,972 | 9,999,978 | 7,794,996 | Aug 16 12:00 AM |
| ZYME | EcoR1 Capital, LLC | 10% Owner | Dec 26 '23 | Buy | 0.00 | 5,086,521 | 509 | 5,086,521 | Dec 28 12:00 AM |
| ZYME | EcoR1 Capital, LLC | 10% Owner | Jun 16 '23 | Buy | 8.12 | 3,350,000 | 27,202,000 | 13,437,473 | Jun 21 12:00 AM |
| ZYME | EcoR1 Capital, LLC | 10% Owner | Mar 28 '23 | Buy | 8.00 | 200,000 | 1,600,000 | 10,087,473 | Mar 30 12:00 AM |
| ZYME | EcoR1 Capital, LLC | Director | Jan 20 '23 | Buy | 9.88 | 163,400 | 1,615,095 | 9,887,473 | Jan 23 12:00 AM |
| ZYME | EcoR1 Capital, LLC | Director | Jan 19 '23 | Buy | 9.49 | 144,100 | 1,367,639 | 9,724,073 | Jan 23 12:00 AM |
| ZYME | EcoR1 Capital, LLC | Director | Jan 18 '23 | Buy | 10.00 | 203,000 | 2,029,046 | 9,579,973 | Jan 18 12:00 AM |
| ZYME | EcoR1 Capital, LLC | Director | Jan 17 '23 | Buy | 9.80 | 440,000 | 4,313,848 | 9,376,973 | Jan 18 12:00 AM |
| ZYME | EcoR1 Capital, LLC | Director | Jan 13 '23 | Buy | 9.81 | 342,100 | 3,354,633 | 8,936,973 | Jan 18 12:00 AM |
| ZYME | EcoR1 Capital, LLC | Director | Jan 11 '23 | Buy | 7.87 | 106,300 | 836,911 | 8,594,873 | Jan 12 12:00 AM |
| ZYME | EcoR1 Capital, LLC | Director | Jan 10 '23 | Buy | 7.65 | 920,000 | 7,037,172 | 8,488,573 | Jan 12 12:00 AM |
| ANAB | EcoR1 Capital, LLC | 10% Owner | May 05 '22 | Buy | 21.63 | 668,237 | 14,453,966 | 7,521,024 | May 09 12:00 AM |
| ANAB | EcoR1 Capital, LLC | 10% Owner | May 05 '22 | Sale | 21.63 | 668,237 | 14,453,966 | 7,521,024 | May 09 12:00 AM |
| PRTA | EcoR1 Capital, LLC | director: | May 05 '22 | Sale | 29.02 | 1,062,736 | 30,840,599 | 11,584,280 | May 09 12:00 AM |
| PRTA | EcoR1 Capital, LLC | director: | May 05 '22 | Buy | 29.02 | 1,062,736 | 30,840,599 | 11,584,280 | May 09 12:00 AM |
| CRVS | EcoR1 Capital, LLC | 10% Owner | Oct 01 '21 | Sale | 4.96 | 2,000,000 | 9,928,800 | 81,077 | Oct 01 12:00 AM |
| CRVS | EcoR1 Capital, LLC | 10% Owner | Sep 30 '21 | Sale | 5.04 | 3,000,000 | 15,131,100 | 2,081,077 | Oct 01 12:00 AM |
| ANAB | EcoR1 Capital, LLC | director, 10 percent owner: | May 04 '21 | Buy | 23.25 | 165,000 | 3,835,755 | 7,520,424 | May 04 12:00 AM |
| ANAB | EcoR1 Capital, LLC | director, 10 percent owner: | May 03 '21 | Buy | 23.31 | 20,800 | 484,873 | 7,355,424 | May 04 12:00 AM |
| ANAB | EcoR1 Capital, LLC | director, 10 percent owner: | Apr 30 '21 | Buy | 23.16 | 35,700 | 826,816 | 7,334,624 | May 04 12:00 AM |
| ANAB | EcoR1 Capital, LLC | director, 10 percent owner: | Apr 27 '21 | Buy | 23.82 | 33,800 | 805,089 | 7,298,924 | Apr 27 12:00 AM |
| ANAB | EcoR1 Capital, LLC | director, 10 percent owner: | Apr 26 '21 | Buy | 23.80 | 13,900 | 330,859 | 7,265,124 | Apr 27 12:00 AM |
| ANAB | EcoR1 Capital, LLC | director, 10 percent owner: | Apr 23 '21 | Buy | 23.54 | 99,600 | 2,344,285 | 7,251,224 | Apr 27 12:00 AM |
| ANAB | EcoR1 Capital, LLC | 10% Owner | Mar 09 '21 | Buy | 18.70 | 531,000 | 9,928,426 | 7,151,624 | Mar 10 12:00 AM |
| ANAB | EcoR1 Capital, LLC | 10% Owner | Mar 08 '21 | Buy | 18.97 | 2,777,800 | 52,694,310 | 6,620,624 | Mar 10 12:00 AM |
| ANAB | EcoR1 Capital, LLC | 10% Owner | Feb 23 '21 | Buy | 25.48 | 29,500 | 751,657 | 3,842,824 | Feb 25 12:00 AM |