| MLYS | RA CAPITAL MANAGEMENT, L.P. | Director | Mar 30 '26 | Buy | 24.16 | 58,300 | 1,408,528 | 5,825,521 | Mar 31 12:00 AM |
| MLYS | RA CAPITAL MANAGEMENT, L.P. | Director | Mar 27 '26 | Buy | 23.67 | 310,700 | 7,354,269 | 5,767,221 | Mar 31 12:00 AM |
| WVE | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Mar 30 '26 | Buy | 6.50 | 971,091 | 6,312,092 | 26,975,505 | Mar 30 12:00 AM |
| WVE | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Mar 27 '26 | Buy | 6.43 | 2,495,623 | 16,046,856 | 26,004,414 | Mar 30 12:00 AM |
| WVE | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Mar 26 '26 | Buy | 6.08 | 5,305,782 | 32,265,430 | 23,508,791 | Mar 30 12:00 AM |
| BCAX | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Feb 26 '26 | Buy | 1.92 | 2,500,000 | 4,800,220 | 4,603,418 | Mar 02 12:00 AM |
| CLYM | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Jan 05 '26 | Buy | 3.50 | 7,111 | 24,889 | 3,403,429 | Jan 07 12:00 AM |
| CLYM | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Dec 12 '25 | Buy | 2.86 | 101,462 | 290,181 | 3,396,318 | Dec 15 12:00 AM |
| CLYM | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Dec 11 '25 | Buy | 2.18 | 213,099 | 464,556 | 3,294,856 | Dec 15 12:00 AM |
| SION | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Nov 21 '25 | Sale | 39.50 | 25,183 | 994,729 | 159,033 | Nov 24 12:00 AM |
| SION | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Nov 20 '25 | Sale | 40.13 | 5,133 | 205,976 | 166,642 | Nov 24 12:00 AM |
| SION | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Nov 19 '25 | Sale | 40.01 | 47,442 | 1,898,172 | 168,193 | Nov 19 12:00 AM |
| SION | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Nov 18 '25 | Sale | 39.57 | 6,922 | 273,903 | 182,527 | Nov 19 12:00 AM |
| SION | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Nov 17 '25 | Sale | 40.59 | 81,987 | 3,328,080 | 184,619 | Nov 19 12:00 AM |
| WVE | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Nov 13 '25 | Buy | 6.69 | 1,000 | 6,688 | 18,203,009 | Nov 14 12:00 AM |
| SION | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Oct 28 '25 | Sale | 39.58 | 62,610 | 2,478,103 | 209,391 | Oct 28 12:00 AM |
| SION | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Oct 24 '25 | Sale | 39.50 | 311,000 | 12,284,501 | 219,867 | Oct 28 12:00 AM |
| MLYS | RA CAPITAL MANAGEMENT, L.P. | Director | Sep 04 '25 | Buy | 25.50 | 1,176,470 | 29,999,985 | 5,456,521 | Sep 08 12:00 AM |
| TYRA | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Jun 16 '25 | Buy | 10.13 | 11,813 | 119,666 | 10,259,291 | Jun 16 12:00 AM |
| TYRA | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Jun 13 '25 | Buy | 10.20 | 120,167 | 1,225,703 | 10,247,478 | Jun 16 12:00 AM |
| TYRA | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Jun 12 '25 | Buy | 10.20 | 31,307 | 319,331 | 10,127,311 | Jun 16 12:00 AM |
| TYRA | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Jun 09 '25 | Buy | 10.19 | 186,850 | 1,904,002 | 10,096,004 | Jun 11 12:00 AM |
| TYRA | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Jun 05 '25 | Buy | 10.04 | 213,334 | 2,141,873 | 9,909,154 | Jun 06 12:00 AM |
| TYRA | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Jun 04 '25 | Buy | 9.63 | 997,864 | 9,609,430 | 9,695,820 | Jun 06 12:00 AM |
| MLYS | RA CAPITAL MANAGEMENT, L.P. | Director | Mar 13 '25 | Buy | 13.50 | 1,296,296 | 17,499,996 | 4,280,051 | Mar 17 12:00 AM |
| JANX | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Mar 07 '25 | Buy | 31.02 | 110,206 | 3,418,590 | 10,141,287 | Mar 07 12:00 AM |
| JANX | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Mar 06 '25 | Buy | 30.78 | 372,093 | 11,453,023 | 10,031,081 | Mar 07 12:00 AM |
| JANX | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Mar 05 '25 | Buy | 30.64 | 341,742 | 10,471,353 | 9,658,988 | Mar 07 12:00 AM |
| SLDB | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | Feb 19 '25 | Buy | 0.00 | 3,722,085 | 3,722 | 3,722,085 | Feb 21 12:00 AM |
| TYRA | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Nov 08 '24 | Buy | 16.25 | 1,220,681 | 19,836,066 | 8,697,956 | Nov 13 12:00 AM |
| JANX | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Oct 18 '24 | Buy | 44.75 | 1,200,000 | 53,700,000 | 9,317,246 | Oct 22 12:00 AM |
| BCAX | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Sep 16 '24 | Buy | 18.00 | 1,833,000 | 32,994,000 | 4,303,418 | Sep 18 12:00 AM |
| SPRY | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Mar 27 '24 | Buy | 9.79 | 505,954 | 4,953,290 | 9,958,073 | Mar 27 12:00 AM |
| SPRY | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Mar 26 '24 | Buy | 9.55 | 457,745 | 4,371,465 | 9,452,119 | Mar 27 12:00 AM |
| SPRY | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Mar 25 '24 | Buy | 9.06 | 437,600 | 3,964,656 | 8,994,374 | Mar 27 12:00 AM |
| JANX | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Mar 04 '24 | Buy | 0.00 | 1,397,849 | 1,398 | 1,397,849 | Mar 06 12:00 AM |
| WVE | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Dec 11 '23 | Buy | 5.00 | 2,000,000 | 10,000,000 | 19,202,009 | Jan 17 12:00 AM |
| SLDB | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Jan 11 '24 | Buy | 5.53 | 904,160 | 5,000,005 | 4,192,216 | Jan 12 12:00 AM |
| SPRY | RA CAPITAL MANAGEMENT, L.P. | Director | Sep 21 '23 | Buy | 3.03 | 2,700,000 | 8,183,525 | 8,556,774 | Sep 25 12:00 AM |
| SPRY | RA CAPITAL MANAGEMENT, L.P. | Director | Aug 29 '23 | Buy | 6.20 | 3,750,000 | 23,250,000 | 5,856,774 | Aug 31 12:00 AM |
| JANX | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Jul 19 '23 | Buy | 6.18 | 998,234 | 6,168,303 | 8,117,246 | Jul 21 12:00 AM |
| MLYS | RA CAPITAL MANAGEMENT, L.P. | Director | Feb 14 '23 | Buy | 16.00 | 1,250,000 | 20,000,000 | 1,867,229 | Feb 16 12:00 AM |
| WVE | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Jun 16 '22 | Buy | 1.23 | 16,573,708 | 20,382,821 | 17,202,009 | Jun 21 12:00 AM |
| TYRA | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Sep 17 '21 | Buy | 16.00 | 1,250,000 | 20,000,000 | 5,297,120 | Sep 17 12:00 AM |
| JANX | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Jun 15 '21 | Buy | 17.00 | 2,941,176 | 49,999,992 | 7,622,238 | Jun 16 12:00 AM |
| SLDB | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Mar 19 '21 | Buy | 5.75 | 2,206,685 | 12,688,439 | 10,916,567 | Mar 23 12:00 AM |
| PHAT | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | Mar 11 '21 | Sale | 43.75 | 710,000 | 31,062,500 | 3,115,008 | Mar 15 12:00 AM |
| TGTX | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | Sep 09 '20 | Sale | 25.81 | 158,589 | 4,092,738 | 12,629,868 | Sep 11 12:00 AM |
| PHAT | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | Apr 01 '20 | Buy | 24.86 | 117,600 | 2,923,642 | 3,825,008 | Apr 03 12:00 AM |
| PHAT | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | Mar 31 '20 | Buy | 24.55 | 30,600 | 751,264 | 3,707,408 | Mar 31 12:00 AM |
| PHAT | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | Mar 27 '20 | Buy | 24.60 | 30,000 | 738,000 | 3,676,808 | Mar 31 12:00 AM |