| Ticker | Owner | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| SEPN | Third Rock Ventures V, L.P. | 10% Owner | Aug 12 '26 | Sale | 50.27 | 147,200 | 7,399,858 | 6,068,391 | Aug 14 |
| RAPP | Third Rock Ventures V, L.P. | 10% Owner | May 26 '26 | Sale | 40.05 | 18,572 | 743,753 | 6,280,525 | May 28 |
| RAPP | Third Rock Ventures V, L.P. | 10% Owner | May 11 '26 | Sale | 40.24 | 133,618 | 5,377,323 | 6,299,097 | May 13 |
| RAPP | Third Rock Ventures V, L.P. | 10% Owner | May 08 '26 | Sale | 40.31 | 5,018 | 202,256 | 6,432,715 | May 11 |
| RAPP | Third Rock Ventures V, L.P. | 10% Owner | May 07 '26 | Sale | 40.12 | 271,495 | 10,892,651 | 6,437,733 | May 11 |
| RAPP | Third Rock Ventures V, L.P. | 10% Owner | Apr 17 '26 | Sale | 40.32 | 426,005 | 17,175,244 | 6,709,228 | Apr 21 |
| SEPN | Third Rock Ventures V, L.P. | 10% Owner | Oct 28 '24 | Buy | 18.00 | 650,000 | 11,700,000 | 6,215,591 | Oct 28 |