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| Ticker | Owner | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| VRTX | Tatsis Ourania | EVP, Chief Reg. & Quality Off. | Jul 02 '26 | Sale | 524.99 | 1,500 | 787,485 | 45,321 | Jul 07 |
| VRTX | Tatsis Ourania | EVP, Chief Reg. & Quality Off. | Feb 25 '26 | Sale | 486.35 | 260 | 126,451 | 46,763 | Feb 26 |
| VRTX | Tatsis Ourania | EVP, Chief Reg. & Quality Off. | Feb 18 '26 | Sale | 473.68 | 368 | 174,314 | 48,650 | Feb 19 |
| VRTX | Tatsis Ourania | EVP, Chief Reg. & Quality Off. | Feb 17 '26 | Sale | 489.46 | 609 | 298,081 | 49,018 | Feb 19 |
| VRTX | Tatsis Ourania | EVP, Chief Reg. & Quality Off. | Feb 13 '26 | Sale | 499.99 | 1,500 | 749,985 | 46,132 | Feb 18 |
| VRTX | Tatsis Ourania | EVP, Chief Reg. & Quality Off. | Feb 11 '26 | Sale | 460.43 | 466 | 214,560 | 51,436 | Feb 12 |
| VRTX | Tatsis Ourania | EVP, Chief Reg. & Quality Off. | Jan 07 '26 | Sale | 474.99 | 4,500 | 2,137,455 | 42,293 | Jan 09 |
| VRTX | Tatsis Ourania | EVP, Chief Reg. & Quality Off. | Dec 03 '25 | Sale | 449.99 | 4,500 | 2,024,955 | 46,793 | Dec 05 |
| VRTX | Tatsis Ourania | EVP, Chief Reg. & Quality Off. | Mar 10 '25 | Sale | 499.99 | 3,242 | 1,620,968 | 51,239 | Mar 12 |
| VRTX | Tatsis Ourania | EVP, Chief Reg. & Quality Off. | Mar 04 '25 | Sale | 485.49 | 4,058 | 1,970,118 | 54,481 | Mar 06 |
| VRTX | Tatsis Ourania | EVP, Chief Reg. & Quality Off. | Feb 27 '25 | Sale | 475.34 | 530 | 251,930 | 58,539 | Feb 28 |
| VRTX | Tatsis Ourania | EVP, Chief Reg. & Quality Off. | Feb 25 '25 | Sale | 480.95 | 354 | 170,256 | 64,031 | Feb 26 |
| VRTX | Tatsis Ourania | EVP, Chief Reg. & Quality Off. | Feb 18 '25 | Sale | 455.06 | 244 | 111,035 | 67,695 | Feb 19 |
| VRTX | Tatsis Ourania | EVP, Chief Reg. & Quality Off. | Feb 11 '25 | Sale | 459.83 | 310 | 142,547 | 64,021 | Feb 12 |
| VRTX | Tatsis Ourania | EVP, Chief Reg. & Quality Off. | Jun 03 '24 | Sale | 460.00 | 2,175 | 1,000,500 | 49,098 | Jun 05 |
| VRTX | Tatsis Ourania | EVP, Chief Reg. & Quality Off. | May 31 '24 | Sale | 445.00 | 2,250 | 1,001,250 | 51,273 | Jun 03 |
| VRTX | Tatsis Ourania | EVP, Chief Reg. & Quality Off. | May 30 '24 | Sale | 439.11 | 2,350 | 1,031,909 | 53,523 | Jun 03 |
| VRTX | Tatsis Ourania | EVP, Chief Reg. & Quality Off. | Feb 26 '24 | Sale | 425.70 | 354 | 150,698 | 55,804 | Feb 27 |
| VRTX | Tatsis Ourania | EVP, Chief Reg. & Quality Off. | Feb 21 '24 | Sale | 421.77 | 360 | 151,837 | 59,467 | Feb 23 |
| VRTX | Tatsis Ourania | EVP, Chief Reg. & Quality Off. | Feb 20 '24 | Sale | 420.79 | 480 | 201,979 | 59,827 | Feb 21 |
| VRTX | Tatsis Ourania | EVP, Chief Reg. & Quality Off. | Feb 12 '24 | Sale | 420.24 | 314 | 131,955 | 68,179 | Feb 13 |