Monia Brett P – Insider Transactions

Ticker	Owner	Relationship	Date	Transaction	Cost	#Shares	Value ($)	#Shares Total	SEC Form 4
IONS	Monia Brett P	Chief Executive Officer	May 14 '26	Option Exercise	32.60	6,440	209,944	245,882	May 15 12:00 AM
IONS	Monia Brett P	Chief Executive Officer	May 14 '26	Sale	78.68	3,220	253,347	242,662	May 15 12:00 AM
IONS	Monia Brett P	Chief Executive Officer	May 13 '26	Sale	78.01	1,316	102,665	242,662	May 15 12:00 AM
IONS	Monia Brett P	Chief Executive Officer	May 13 '26	Option Exercise	32.60	2,632	85,804	243,978	May 15 12:00 AM
IONS	Monia Brett P	Chief Executive Officer	Feb 06 '26	Sale	85.79	29,430	2,524,820	254,497	Feb 10 12:00 AM
IONS	Monia Brett P	Chief Executive Officer	Jan 30 '26	Sale	82.72	62,970	5,208,979	283,927	Feb 02 12:00 AM
IONS	Monia Brett P	Chief Executive Officer	Jan 16 '26	Sale	74.82	44,034	3,294,624	224,683	Jan 20 12:00 AM
IONS	Monia Brett P	Chief Executive Officer	Jan 15 '26	Option Exercise	0.00	178,290	0	268,717	Jan 20 12:00 AM
IONS	Monia Brett P	Chief Executive Officer	Oct 06 '25	Sale	69.26	437	30,268	179,572	Oct 08 12:00 AM
IONS	Monia Brett P	Chief Executive Officer	Sep 03 '25	Option Exercise	44.32	407,628	18,064,078	308,324	Sep 04 12:00 AM
IONS	Monia Brett P	Chief Executive Officer	Sep 03 '25	Sale	60.32	203,814	12,294,703	180,009	Sep 04 12:00 AM
IONS	Monia Brett P	Chief Executive Officer	Jul 30 '25	Option Exercise	32.60	4,864	158,566	182,252	Aug 01 12:00 AM
IONS	Monia Brett P	Chief Executive Officer	Jul 30 '25	Sale	45.00	2,432	109,440	179,820	Aug 01 12:00 AM
IONS	Monia Brett P	Chief Executive Officer	Jul 11 '25	Sale	41.74	1,160	48,416	179,820	Jul 15 12:00 AM

Insider Trading & Congressional Trades