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| Ticker | Owner | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| AGIO | Milanova Tsveta | Chief Commercial Officer | Apr 02 '26 | Option Exercise | 0.00 | 17,000 | 0 | 50,091 | Apr 06 12:00 AM |
| AGIO | Milanova Tsveta | Chief Commercial Officer | Apr 02 '26 | Sale | 34.71 | 3,262 | 113,224 | 46,829 | Apr 06 12:00 AM |
| AGIO | Milanova Tsveta | Chief Commercial Officer | Mar 02 '26 | Option Exercise | 0.00 | 19,332 | 0 | 42,778 | Mar 03 12:00 AM |
| AGIO | Milanova Tsveta | Chief Commercial Officer | Mar 02 '26 | Sale | 28.96 | 2,868 | 83,058 | 38,778 | Mar 03 12:00 AM |
| AGIO | Milanova Tsveta | Chief Commercial Officer | Jan 05 '26 | Option Exercise | 0.00 | 16,950 | 0 | 37,665 | Jan 07 12:00 AM |
| AGIO | Milanova Tsveta | Chief Commercial Officer | Jan 05 '26 | Sale | 27.02 | 2,872 | 77,601 | 34,793 | Jan 07 12:00 AM |
| AGIO | Milanova Tsveta | Chief Commercial Officer | Dec 30 '25 | Option Exercise | 0.00 | 12,000 | 0 | 32,122 | Jan 02 12:00 AM |
| AGIO | Milanova Tsveta | Chief Commercial Officer | Dec 30 '25 | Sale | 27.09 | 2,932 | 79,428 | 29,190 | Jan 02 12:00 AM |
| AGIO | Milanova Tsveta | Chief Commercial Officer | Jun 24 '25 | Option Exercise | 0.00 | 12,000 | 0 | 28,892 | Jun 26 12:00 AM |
| AGIO | Milanova Tsveta | Chief Commercial Officer | Jun 24 '25 | Sale | 33.54 | 2,770 | 92,906 | 26,122 | Jun 26 12:00 AM |
| AGIO | Milanova Tsveta | Chief Commercial Officer | Mar 03 '25 | Sale | 35.54 | 1,681 | 59,743 | 22,892 | Mar 04 12:00 AM |
| AGIO | Milanova Tsveta | Chief Commercial Officer | Mar 01 '25 | Option Exercise | 0.00 | 11,334 | 0 | 24,573 | Mar 04 12:00 AM |
| AGIO | Milanova Tsveta | Chief Commercial Officer | Jan 06 '25 | Sale | 32.18 | 2,804 | 90,233 | 18,906 | Jan 07 12:00 AM |
| AGIO | Milanova Tsveta | Chief Commercial Officer | Jan 03 '25 | Option Exercise | 0.00 | 16,952 | 0 | 21,710 | Jan 07 12:00 AM |
| AGIO | Milanova Tsveta | Chief Commercial Officer | Jan 24 '24 | Sale | 21.64 | 1,618 | 35,014 | 13,234 | Jan 24 12:00 AM |
| AGIO | Milanova Tsveta | Chief Commercial Officer | Jan 20 '24 | Option Exercise | 0.00 | 10,896 | 0 | 14,852 | Jan 24 12:00 AM |
| AGIO | Milanova Tsveta | Chief Commercial Officer | Jan 05 '24 | Sale | 22.32 | 2,902 | 64,773 | 9,404 | Jan 05 12:00 AM |
| AGIO | Milanova Tsveta | Chief Commercial Officer | Jan 03 '24 | Option Exercise | 0.00 | 16,950 | 0 | 16,951 | Jan 05 12:00 AM |
| AGIO | Milanova Tsveta | Chief Commercial Officer | Jun 30 '23 | Sale | 28.36 | 1,618 | 45,886 | 3,831 | Jun 30 12:00 AM |
| AGIO | Milanova Tsveta | Chief Commercial Officer | Jun 28 '23 | Option Exercise | 0.00 | 10,898 | 0 | 5,449 | Jun 30 12:00 AM |