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| Ticker | Owner | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| INSM | Lewis William | Chair and CEO | Jun 08 '26 | Sale | 94.03 | 6,515 | 612,605 | 258,917 | Jun 10 12:00 AM |
| INSM | Lewis William | Chair and CEO | Jun 03 '26 | Sale | 102.27 | 7,605 | 777,763 | 265,432 | Jun 05 12:00 AM |
| INSM | Lewis William | Chair and CEO | May 18 '26 | Option Exercise | 24.94 | 21,398 | 533,678 | 298,601 | May 20 12:00 AM |
| INSM | Lewis William | Chair and CEO | May 18 '26 | Sale | 106.33 | 25,564 | 2,718,224 | 273,037 | May 20 12:00 AM |
| INSM | Lewis William | Chair and CEO | May 13 '26 | Sale | 116.18 | 13,283 | 1,543,219 | 287,902 | May 15 12:00 AM |
| INSM | Lewis William | Chair and CEO | May 04 '26 | Sale | 137.34 | 10,699 | 1,469,442 | 301,185 | May 06 12:00 AM |
| INSM | Lewis William | Chair and CEO | May 04 '26 | Option Exercise | 24.94 | 21,398 | 533,678 | 311,884 | May 06 12:00 AM |
| INSM | Lewis William | Chair and CEO | Apr 16 '26 | Option Exercise | 24.94 | 21,398 | 533,678 | 311,884 | Apr 17 12:00 AM |
| INSM | Lewis William | Chair and CEO | Apr 16 '26 | Sale | 143.97 | 10,699 | 1,540,332 | 301,185 | Apr 17 12:00 AM |
| INSM | Lewis William | Chair and CEO | Apr 06 '26 | Option Exercise | 24.94 | 21,398 | 533,678 | 311,884 | Apr 08 12:00 AM |
| INSM | Lewis William | Chair and CEO | Apr 06 '26 | Sale | 163.22 | 10,699 | 1,746,336 | 301,185 | Apr 08 12:00 AM |
| INSM | Lewis William | Chair and CEO | Mar 19 '26 | Sale | 143.52 | 10,699 | 1,535,543 | 301,185 | Mar 20 12:00 AM |
| INSM | Lewis William | Chair and CEO | Mar 19 '26 | Option Exercise | 24.94 | 21,398 | 533,678 | 311,884 | Mar 20 12:00 AM |
| INSM | Lewis William | Chair and CEO | Mar 05 '26 | Option Exercise | 24.94 | 21,398 | 533,678 | 311,884 | Mar 05 12:00 AM |
| INSM | Lewis William | Chair and CEO | Mar 05 '26 | Sale | 146.03 | 10,699 | 1,562,327 | 301,185 | Mar 05 12:00 AM |
| INSM | Lewis William | Chair and CEO | Feb 19 '26 | Option Exercise | 24.94 | 21,398 | 533,678 | 311,884 | Feb 23 12:00 AM |
| INSM | Lewis William | Chair and CEO | Feb 19 '26 | Sale | 150.97 | 10,699 | 1,615,257 | 301,185 | Feb 23 12:00 AM |
| INSM | Lewis William | Chair and CEO | Feb 09 '26 | Option Exercise | 24.94 | 21,398 | 533,678 | 314,581 | Feb 11 12:00 AM |
| INSM | Lewis William | Chair and CEO | Feb 09 '26 | Sale | 147.79 | 13,396 | 1,979,763 | 301,185 | Feb 11 12:00 AM |
| INSM | Lewis William | Chair and CEO | Feb 03 '26 | Sale | 156.34 | 3,009 | 470,427 | 303,882 | Feb 04 12:00 AM |
| INSM | Lewis William | Chair and CEO | Jan 20 '26 | Sale | 158.93 | 10,699 | 1,700,412 | 306,891 | Jan 22 12:00 AM |
| INSM | Lewis William | Chair and CEO | Jan 20 '26 | Option Exercise | 24.94 | 21,398 | 533,678 | 317,590 | Jan 22 12:00 AM |
| INSM | Lewis William | Chair and CEO | Jan 12 '26 | Option Exercise | 24.94 | 21,398 | 533,678 | 326,106 | Jan 13 12:00 AM |
| INSM | Lewis William | Chair and CEO | Jan 12 '26 | Sale | 169.00 | 19,215 | 3,247,349 | 306,891 | Jan 13 12:00 AM |
| INSM | Lewis William | Chair and CEO | Jan 08 '26 | Sale | 174.17 | 3,223 | 561,350 | 315,407 | Jan 08 12:00 AM |
| INSM | Lewis William | Chair and CEO | Jan 07 '26 | Sale | 175.07 | 2,357 | 412,640 | 318,630 | Jan 08 12:00 AM |
| INSM | Lewis William | Chair and CEO | Jan 06 '26 | Sale | 173.33 | 4,096 | 709,960 | 320,987 | Jan 08 12:00 AM |
| INSM | Lewis William | Chair and CEO | Dec 18 '25 | Option Exercise | 24.94 | 21,398 | 533,678 | 314,610 | Dec 19 12:00 AM |
| INSM | Lewis William | Chair and CEO | Dec 18 '25 | Sale | 166.97 | 10,699 | 1,786,456 | 303,911 | Dec 19 12:00 AM |
| INSM | Lewis William | Chair and CEO | Dec 04 '25 | Option Exercise | 24.94 | 21,398 | 533,678 | 314,610 | Dec 05 12:00 AM |
| INSM | Lewis William | Chair and CEO | Dec 04 '25 | Sale | 205.62 | 10,699 | 2,199,915 | 303,911 | Dec 05 12:00 AM |
| INSM | Lewis William | Chair and CEO | Aug 18 '25 | Option Exercise | 10.85 | 13,730 | 148,970 | 240,789 | Aug 20 12:00 AM |
| INSM | Lewis William | Chair and CEO | Aug 18 '25 | Sale | 128.40 | 6,865 | 881,471 | 233,924 | Aug 20 12:00 AM |
| INSM | Lewis William | Chair and CEO | Aug 04 '25 | Option Exercise | 10.85 | 13,660 | 148,212 | 240,754 | Aug 06 12:00 AM |
| INSM | Lewis William | Chair and CEO | Aug 04 '25 | Sale | 109.81 | 6,830 | 750,008 | 233,924 | Aug 06 12:00 AM |
| INSM | Lewis William | Chair and CEO | Jul 15 '25 | Option Exercise | 10.85 | 13,660 | 148,212 | 240,754 | Jul 15 12:00 AM |
| INSM | Lewis William | Chair and CEO | Jul 15 '25 | Sale | 102.37 | 6,830 | 699,220 | 233,924 | Jul 15 12:00 AM |
| INSM | Lewis William | Chair and CEO | Jul 01 '25 | Sale | 98.33 | 6,830 | 671,612 | 233,924 | Jul 02 12:00 AM |
| INSM | Lewis William | Chair and CEO | Jul 01 '25 | Option Exercise | 10.85 | 13,660 | 148,212 | 240,754 | Jul 02 12:00 AM |
| INSM | Lewis William | Chair and CEO | Jun 16 '25 | Sale | 100.39 | 135,009 | 13,553,744 | 233,924 | Jun 18 12:00 AM |
| INSM | Lewis William | Chair and CEO | Jun 16 '25 | Option Exercise | 10.85 | 259,610 | 2,816,768 | 363,729 | Jun 18 12:00 AM |
| INSM | Lewis William | Chair and CEO | Jun 03 '25 | Sale | 71.50 | 5,472 | 391,248 | 308,758 | Jun 04 12:00 AM |
| INSM | Lewis William | Chair and CEO | Jun 02 '25 | Sale | 71.31 | 6,830 | 487,044 | 233,924 | Jun 04 12:00 AM |
| INSM | Lewis William | Chair and CEO | Jun 02 '25 | Option Exercise | 10.85 | 13,660 | 148,212 | 240,754 | Jun 04 12:00 AM |
| INSM | Lewis William | Chair and CEO | May 20 '25 | Sale | 67.66 | 27,887 | 1,886,958 | 233,924 | May 22 12:00 AM |
| INSM | Lewis William | Chair and CEO | May 20 '25 | Option Exercise | 10.85 | 13,660 | 148,212 | 240,754 | May 22 12:00 AM |
| INSM | Lewis William | Chair and CEO | May 14 '25 | Sale | 65.61 | 3,771 | 247,415 | 312,973 | May 15 12:00 AM |
| INSM | Lewis William | Chair and CEO | May 13 '25 | Sale | 66.97 | 17,442 | 1,168,157 | 316,744 | May 15 12:00 AM |
| INSM | Lewis William | Chair and CEO | May 01 '25 | Option Exercise | 10.85 | 13,660 | 148,212 | 240,754 | May 02 12:00 AM |
| INSM | Lewis William | Chair and CEO | May 01 '25 | Sale | 72.57 | 6,830 | 495,668 | 233,924 | May 02 12:00 AM |
| INSM | Lewis William | Chair and CEO | Apr 15 '25 | Option Exercise | 10.85 | 13,660 | 148,212 | 240,754 | Apr 16 12:00 AM |
| INSM | Lewis William | Chair and CEO | Apr 15 '25 | Sale | 70.16 | 6,830 | 479,177 | 233,924 | Apr 16 12:00 AM |
| INSM | Lewis William | Chair and CEO | Apr 01 '25 | Option Exercise | 10.85 | 13,660 | 148,212 | 240,754 | Apr 03 12:00 AM |
| INSM | Lewis William | Chair and CEO | Apr 01 '25 | Sale | 73.58 | 6,830 | 502,577 | 233,924 | Apr 03 12:00 AM |
| INSM | Lewis William | Chair and CEO | Mar 17 '25 | Option Exercise | 19.58 | 51,160 | 1,001,712 | 352,936 | Mar 19 12:00 AM |
| INSM | Lewis William | Chair and CEO | Mar 17 '25 | Sale | 77.03 | 25,580 | 1,970,422 | 233,924 | Mar 19 12:00 AM |
| INSM | Lewis William | Chair and CEO | Mar 03 '25 | Option Exercise | 19.58 | 25,580 | 500,856 | 352,936 | Mar 05 12:00 AM |
| INSM | Lewis William | Chair and CEO | Mar 03 '25 | Sale | 77.75 | 25,157 | 1,956,017 | 234,347 | Mar 05 12:00 AM |