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| Ticker | Owner | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| AXSM | Jacobson Mark L. | Chief Operating Officer | Sep 03 '26 | Sale | 208.65 | 10,000 | 2,086,500 | 0 | Sep 03 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | Sep 03 '26 | Option Exercise | 12.95 | 10,000 | 129,500 | 10,000 | Sep 03 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | May 05 '26 | Option Exercise | 12.95 | 233 | 3,017 | 233 | May 05 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | May 05 '26 | Sale | 228.18 | 233 | 53,166 | 0 | May 05 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | May 04 '26 | Sale | 227.94 | 4,517 | 1,029,605 | 0 | May 05 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | May 04 '26 | Option Exercise | 12.95 | 4,517 | 58,495 | 4,517 | May 05 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | Feb 26 '26 | Sale | 161.88 | 35,378 | 5,726,991 | 0 | Feb 27 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | Feb 26 '26 | Option Exercise | 2.85 | 35,378 | 100,827 | 35,378 | Feb 27 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | Sep 22 '25 | Option Exercise | 2.85 | 10,000 | 28,500 | 10,000 | Sep 22 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | Sep 22 '25 | Sale | 115.96 | 10,000 | 1,159,600 | 0 | Sep 22 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | Sep 16 '25 | Option Exercise | 4.91 | 40,000 | 196,500 | 40,000 | Sep 17 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | Sep 16 '25 | Sale | 114.48 | 45,783 | 5,241,127 | 0 | Sep 17 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | Jun 09 '25 | Option Exercise | 8.02 | 25,000 | 200,500 | 30,783 | Jun 10 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | Jun 09 '25 | Sale | 110.44 | 25,000 | 2,761,000 | 5,783 | Jun 10 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | May 28 '25 | Option Exercise | 6.47 | 20,000 | 129,400 | 25,783 | May 28 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | May 28 '25 | Sale | 103.45 | 20,000 | 2,069,000 | 5,783 | May 28 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | May 27 '25 | Sale | 104.66 | 20,673 | 2,163,636 | 5,783 | May 28 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | May 27 '25 | Option Exercise | 6.47 | 20,673 | 133,754 | 26,456 | May 28 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | Aug 09 '24 | Option Exercise | 4.04 | 47,739 | 192,866 | 53,522 | Aug 09 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | Aug 09 '24 | Sale | 84.26 | 47,739 | 4,022,488 | 5,783 | Aug 09 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | May 29 '24 | Option Exercise | 1.30 | 13,693 | 17,801 | 13,693 | May 29 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | May 29 '24 | Sale | 74.31 | 7,910 | 587,813 | 5,783 | May 29 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | Apr 01 '24 | Option Exercise | 1.30 | 24,662 | 32,061 | 24,662 | Apr 01 |
| AXSM | Jacobson Mark L. | Chief Operating Officer | Apr 01 '24 | Sale | 77.24 | 24,662 | 1,904,942 | 0 | Apr 01 |