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| Ticker | Owner | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Mar 04 '26 | Sale | 323.08 | 2,933 | 947,581 | 95,695 | Mar 06 |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Mar 02 '26 | Sale | 327.65 | 6,799 | 2,227,698 | 98,628 | Mar 04 |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Feb 27 '26 | Option Exercise | 0.00 | 5,921 | 0 | 91,583 | Mar 02 |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Feb 13 '26 | Sale | 310.08 | 6,958 | 2,157,542 | 85,662 | Feb 17 |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Jan 12 '26 | Sale | 362.86 | 9,577 | 3,475,158 | 78,411 | Jan 14 |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Nov 26 '25 | Option Exercise | 106.40 | 4,697 | 499,756 | 70,106 | Dec 01 |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Nov 13 '25 | Option Exercise | 119.13 | 10,000 | 1,191,300 | 75,409 | Nov 14 |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Nov 13 '25 | Sale | 451.27 | 10,000 | 4,512,682 | 65,409 | Nov 14 |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Nov 12 '25 | Option Exercise | 115.94 | 15,650 | 1,814,393 | 81,059 | Nov 14 |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Nov 12 '25 | Sale | 453.69 | 15,650 | 7,100,322 | 65,409 | Nov 14 |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Oct 02 '25 | Sale | 452.05 | 8,924 | 4,034,085 | 65,409 | Oct 03 |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Aug 18 '25 | Sale | 453.27 | 6,979 | 3,163,345 | 56,221 | Aug 19 |