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| Ticker | Owner | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| ORKA | Goncalves Joana | Chief Medical Officer | Jul 15 '26 | Sale | 86.28 | 7,000 | 603,937 | 32,718 | Jul 15 |
| ORKA | Goncalves Joana | Chief Medical Officer | Jul 15 '26 | Option Exercise | 7.32 | 7,000 | 51,240 | 39,718 | Jul 15 |
| ORKA | Goncalves Joana | Chief Medical Officer | Jun 15 '26 | Option Exercise | 7.32 | 7,000 | 51,240 | 40,665 | Jun 15 |
| ORKA | Goncalves Joana | Chief Medical Officer | Jun 15 '26 | Sale | 69.28 | 7,947 | 550,606 | 32,718 | Jun 15 |
| ORKA | Goncalves Joana | Chief Medical Officer | May 15 '26 | Option Exercise | 7.32 | 7,000 | 51,240 | 40,377 | May 15 |
| ORKA | Goncalves Joana | Chief Medical Officer | May 15 '26 | Sale | 61.85 | 7,000 | 432,935 | 33,377 | May 15 |
| ORKA | Goncalves Joana | Chief Medical Officer | Apr 15 '26 | Option Exercise | 7.32 | 7,000 | 51,240 | 40,377 | Apr 15 |
| ORKA | Goncalves Joana | Chief Medical Officer | Apr 15 '26 | Sale | 66.12 | 7,000 | 462,830 | 33,377 | Apr 15 |
| ORKA | Goncalves Joana | Chief Medical Officer | Mar 16 '26 | Option Exercise | 7.32 | 7,000 | 51,240 | 41,018 | Mar 17 |
| ORKA | Goncalves Joana | Chief Medical Officer | Mar 16 '26 | Sale | 40.91 | 7,641 | 312,560 | 33,377 | Mar 17 |
| ORKA | Goncalves Joana | Chief Medical Officer | Feb 17 '26 | Option Exercise | 7.32 | 7,000 | 51,240 | 41,018 | Feb 17 |
| ORKA | Goncalves Joana | Chief Medical Officer | Feb 17 '26 | Sale | 32.37 | 7,000 | 226,559 | 34,018 | Feb 17 |
| ORKA | Goncalves Joana | Chief Medical Officer | Jan 15 '26 | Option Exercise | 7.32 | 7,000 | 51,240 | 8,518 | Jan 16 |
| ORKA | Goncalves Joana | Chief Medical Officer | Jan 15 '26 | Sale | 31.81 | 7,000 | 222,705 | 1,518 | Jan 16 |
| ORKA | Goncalves Joana | Chief Medical Officer | Dec 19 '25 | Sale | 30.61 | 7,000 | 214,293 | 1,518 | Dec 19 |
| ORKA | Goncalves Joana | Chief Medical Officer | Dec 19 '25 | Option Exercise | 7.32 | 7,000 | 51,240 | 8,518 | Dec 19 |
| CARA | Goncalves Joana | CHIEF MEDICAL OFFICER | Apr 05 '24 | Sale | 0.83 | 2,753 | 2,285 | 53,365 | Apr 09 |
| CARA | Goncalves Joana | CHIEF MEDICAL OFFICER | Feb 29 '24 | Sale | 0.89 | 3,293 | 2,931 | 56,118 | Mar 04 |
| CARA | Goncalves Joana | CHIEF MEDICAL OFFICER | Feb 08 '23 | Sale | 0.53 | 7,770 | 4,118 | 59,411 | Feb 12 |
| CARA | Goncalves Joana | Chief Medical Officer | Jun 23 '23 | Sale | 3.51 | 2,723 | 9,558 | 53,681 | Jun 27 |
| CARA | Goncalves Joana | Chief Medical Officer | Apr 04 '23 | Sale | 4.91 | 2,481 | 12,182 | 56,404 | Apr 06 |
| CARA | Goncalves Joana | Chief Medical Officer | Mar 03 '23 | Sale | 9.71 | 6,221 | 60,406 | 58,885 | Mar 07 |
| CARA | Goncalves Joana | Chief Medical Officer | Feb 16 '23 | Sale | 10.20 | 2,265 | 23,103 | 65,106 | Feb 17 |
| CARA | Goncalves Joana | Chief Medical Officer | Jan 17 '23 | Sale | 10.81 | 2,265 | 24,485 | 67,371 | Jan 19 |
| CARA | Goncalves Joana | Chief Medical Officer | Dec 29 '22 | Sale | 10.18 | 2,265 | 23,058 | 69,636 | Jan 03 |
| CARA | Goncalves Joana | Chief Medical Officer | Dec 21 '22 | Sale | 11.27 | 2,992 | 33,720 | 71,901 | Dec 23 |
| CARA | Goncalves Joana | Chief Medical Officer | Apr 01 '22 | Sale | 11.91 | 1,642 | 19,556 | 74,893 | Apr 05 |
| CARA | Goncalves Joana | Chief Medical Officer | Feb 25 '22 | Sale | 10.29 | 1,972 | 20,292 | 76,535 | Mar 01 |
| CARA | Goncalves Joana | Chief Medical Officer | Nov 01 '21 | Sale | 17.15 | 1,000 | 17,150 | 45,900 | Nov 03 |
| CARA | Goncalves Joana | Chief Medical Officer | Oct 27 '21 | Sale | 15.00 | 1,000 | 15,000 | 46,900 | Oct 28 |
| CARA | Goncalves Joana | Chief Medical Officer | Aug 30 '21 | Sale | 14.20 | 2,110 | 29,962 | 47,900 | Sep 01 |
| CARA | Goncalves Joana | Chief Medical Officer | Apr 21 '21 | Sale | 27.63 | 3,000 | 82,890 | 43,610 | Apr 23 |
| CARA | Goncalves Joana | Chief Medical Officer | Mar 22 '21 | Sale | 19.65 | 3,000 | 58,950 | 30,610 | Mar 24 |
| CARA | Goncalves Joana | Chief Medical Officer | Mar 05 '21 | Sale | 17.98 | 3,093 | 55,612 | 33,610 | Mar 08 |
| CARA | Goncalves Joana | Chief Medical Officer | Feb 25 '21 | Sale | 19.33 | 3,372 | 65,181 | 26,703 | Feb 25 |
| CARA | Goncalves Joana | Chief Medical Officer | Feb 22 '21 | Sale | 19.73 | 2,000 | 39,460 | 26,075 | Feb 24 |
| CARA | Goncalves Joana | Chief Medical Officer | Jan 21 '21 | Sale | 20.12 | 2,000 | 40,240 | 28,075 | Jan 25 |
| CARA | Goncalves Joana | Chief Medical Officer | Dec 30 '20 | Sale | 15.30 | 1,298 | 19,859 | 30,075 | Dec 30 |
| CARA | Goncalves Joana | Chief Medical Officer | Dec 21 '20 | Sale | 15.00 | 2,000 | 30,000 | 27,373 | Dec 23 |
| CARA | Goncalves Joana | Chief Medical Officer | Nov 23 '20 | Sale | 15.31 | 2,000 | 30,620 | 29,373 | Nov 25 |
| CARA | Goncalves Joana | Chief Medical Officer | Nov 10 '20 | Sale | 15.00 | 2,000 | 30,000 | 31,373 | Nov 13 |
| CARA | Goncalves Joana | Chief Medical Officer | Oct 20 '20 | Sale | 15.00 | 2,000 | 30,000 | 33,373 | Oct 22 |
| CARA | Goncalves Joana | Chief Medical Officer | Jun 12 '20 | Sale | 15.20 | 10,627 | 161,530 | 35,373 | Jun 12 |