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| Ticker | Owner | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| AGIO | Gheuens Sarah | Chief Medical Officer | Jul 01 '26 | Option Exercise | 0.00 | 8,375 | 0 | 88,652 | Jul 02 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Jul 01 '26 | Sale | 37.56 | 4,007 | 150,503 | 84,645 | Jul 02 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Jun 18 '26 | Option Exercise | 0.00 | 3,000 | 0 | 9,000 | Jun 23 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Apr 02 '26 | Option Exercise | 0.00 | 8,500 | 0 | 83,217 | Apr 06 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Apr 02 '26 | Sale | 34.71 | 2,940 | 102,047 | 80,277 | Apr 06 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Mar 02 '26 | Option Exercise | 0.00 | 13,666 | 0 | 75,593 | Mar 03 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Mar 02 '26 | Sale | 28.96 | 4,055 | 117,434 | 67,608 | Mar 03 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Dec 30 '25 | Option Exercise | 0.00 | 6,000 | 0 | 67,727 | Jan 02 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Dec 30 '25 | Sale | 27.09 | 2,932 | 79,428 | 64,795 | Jan 02 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Nov 11 '25 | Option Exercise | 25.01 | 2,454 | 61,375 | 64,181 | Nov 13 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Nov 11 '25 | Sale | 43.78 | 2,454 | 107,436 | 61,727 | Nov 13 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Oct 30 '25 | Option Exercise | 25.01 | 200 | 5,002 | 61,927 | Nov 03 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Oct 30 '25 | Sale | 43.81 | 200 | 8,762 | 61,727 | Nov 03 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Oct 27 '25 | Option Exercise | 25.01 | 3,302 | 82,583 | 65,029 | Oct 29 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Oct 27 '25 | Sale | 43.92 | 3,302 | 145,024 | 61,727 | Oct 29 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Jul 09 '25 | Option Exercise | 25.01 | 11,914 | 297,969 | 73,185 | Jul 11 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Jul 09 '25 | Sale | 37.99 | 11,914 | 452,601 | 61,271 | Jul 11 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Jul 01 '25 | Option Exercise | 0.00 | 8,374 | 0 | 65,362 | Jul 03 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Jul 01 '25 | Sale | 34.17 | 4,091 | 139,789 | 61,271 | Jul 03 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Jun 24 '25 | Option Exercise | 0.00 | 6,000 | 0 | 59,897 | Jun 26 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Jun 24 '25 | Sale | 33.54 | 2,909 | 97,568 | 56,988 | Jun 26 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Mar 03 '25 | Sale | 35.54 | 4,005 | 142,338 | 47,098 | Mar 04 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Mar 01 '25 | Option Exercise | 0.00 | 13,500 | 0 | 55,578 | Mar 04 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Jul 01 '24 | Option Exercise | 0.00 | 8,375 | 0 | 47,441 | Jul 03 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Jul 01 '24 | Sale | 43.85 | 3,705 | 162,464 | 43,736 | Jul 03 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Mar 05 '24 | Sale | 32.57 | 2,642 | 86,050 | 36,415 | Mar 05 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Mar 01 '24 | Option Exercise | 0.00 | 7,834 | 0 | 40,415 | Mar 05 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Feb 14 '24 | Sale | 25.14 | 642 | 16,140 | 33,431 | Feb 14 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Feb 12 '24 | Option Exercise | 0.00 | 2,162 | 0 | 34,073 | Feb 14 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Jan 24 '24 | Sale | 21.64 | 1,708 | 36,961 | 31,911 | Jan 24 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Jan 20 '24 | Option Exercise | 0.00 | 5,750 | 0 | 33,619 | Jan 24 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Jan 09 '24 | Sale | 22.99 | 1,789 | 41,129 | 27,869 | Jan 09 |
| AGIO | Gheuens Sarah | Chief Medical Officer | Jan 05 '24 | Option Exercise | 0.00 | 5,000 | 0 | 29,658 | Jan 09 |