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| Ticker | Owner | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Nov 21 '25 | Buy | 1.33 | 580,000 | 768,807 | 216,706,448 | Nov 21 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Nov 20 '25 | Buy | 1.33 | 580,000 | 771,327 | 216,126,448 | Nov 20 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Nov 19 '25 | Buy | 1.31 | 580,000 | 759,117 | 215,546,448 | Nov 19 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Nov 18 '25 | Buy | 1.27 | 533,300 | 678,905 | 214,966,448 | Nov 18 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Oct 31 '25 | Buy | 1.42 | 150,000 | 213,435 | 214,386,448 | Oct 31 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Aug 08 '25 | Buy | 1.32 | 675,000 | 891,000 | 214,676,448 | Aug 08 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Apr 10 '25 | Buy | 1.36 | 125,000 | 169,713 | 214,001,448 | Apr 10 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Apr 08 '25 | Buy | 1.48 | 125,000 | 184,650 | 213,876,448 | Apr 08 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Apr 01 '25 | Buy | 1.65 | 100,000 | 164,850 | 213,751,448 | Apr 01 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Mar 28 '25 | Buy | 1.70 | 150,000 | 254,385 | 213,651,448 | Mar 28 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Mar 17 '25 | Buy | 1.74 | 200,000 | 347,820 | 213,501,448 | Mar 17 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Mar 04 '25 | Buy | 1.15 | 0 | 0 | 0 | Mar 04 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Mar 03 '25 | Buy | 1.15 | 0 | 0 | 0 | Mar 03 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Feb 28 '25 | Buy | 1.71 | 67,434 | 115,312 | 213,301,448 | Feb 28 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Jan 28 '25 | Buy | 1.47 | 47,537 | 70,060 | 213,234,014 | Jan 28 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Jan 17 '25 | Buy | 1.47 | 150,000 | 220,425 | 213,186,477 | Jan 17 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Jan 15 '25 | Buy | 1.48 | 500,000 | 740,850 | 213,036,477 | Jan 15 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Dec 13 '24 | Buy | 1.59 | 125,000 | 199,375 | 212,536,477 | Dec 13 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Dec 11 '24 | Buy | 1.56 | 500,000 | 781,050 | 212,411,477 | Dec 11 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Nov 29 '24 | Buy | 1.53 | 199,072 | 305,376 | 211,911,477 | Nov 29 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Nov 22 '24 | Buy | 1.59 | 100,000 | 159,000 | 211,712,405 | Nov 22 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Nov 14 '24 | Buy | 1.62 | 100,000 | 161,980 | 211,612,405 | Nov 14 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Nov 08 '24 | Buy | 1.50 | 280,183 | 421,535 | 211,512,405 | Nov 08 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Sep 27 '24 | Buy | 1.15 | 0 | 0 | 0 | Sep 27 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Sep 25 '24 | Buy | 1.15 | 0 | 0 | 0 | Sep 26 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | May 23 '24 | Buy | 1.27 | 100,000 | 126,937 | 211,232,222 | May 23 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | May 17 '24 | Buy | 1.29 | 163,997 | 211,195 | 211,132,222 | May 17 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Mar 18 '24 | Buy | 0.87 | 500,000 | 437,100 | 210,968,225 | Mar 18 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Mar 14 '24 | Buy | 0.89 | 500,000 | 444,300 | 210,468,225 | Mar 14 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Mar 13 '24 | Buy | 0.93 | 500,000 | 463,750 | 209,968,225 | Mar 13 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Mar 12 '24 | Buy | 0.93 | 600,000 | 559,380 | 209,468,225 | Mar 12 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Feb 28 '24 | Buy | 0.99 | 500,000 | 496,150 | 208,868,225 | Feb 28 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Feb 21 '24 | Buy | 0.99 | 1,000,000 | 991,700 | 208,368,225 | Feb 21 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Feb 07 '24 | Buy | 0.98 | 1,500,000 | 1,462,800 | 207,368,225 | Feb 07 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Jan 19 '24 | Buy | 0.98 | 500,000 | 488,650 | 205,868,225 | Jan 19 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Jan 18 '24 | Buy | 0.97 | 400,000 | 386,200 | 205,368,225 | Jan 18 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Jan 16 '24 | Buy | 0.95 | 1,000,000 | 954,300 | 204,968,225 | Jan 16 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Jan 11 '24 | Buy | 0.94 | 511,531 | 480,379 | 203,968,225 | Jan 11 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Jan 05 '24 | Buy | 0.90 | 1,500,000 | 1,344,600 | 203,456,694 | Jan 08 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Nov 10 '23 | Buy | 1.25 | 500,000 | 625,463 | 201,956,694 | Nov 13 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Nov 09 '23 | Buy | 1.28 | 500,000 | 641,471 | 201,456,694 | Nov 13 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Aug 17 '23 | Buy | 1.76 | 100,000 | 175,804 | 200,956,694 | Aug 18 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Aug 14 '23 | Buy | 1.75 | 75,000 | 131,260 | 200,856,694 | Aug 15 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Aug 09 '23 | Buy | 1.82 | 100,000 | 181,752 | 200,781,694 | Aug 10 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Aug 07 '23 | Buy | 1.84 | 650,000 | 1,194,998 | 200,681,694 | Aug 08 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Mar 22 '23 | Buy | 1.32 | 200,000 | 264,295 | 200,031,694 | Mar 23 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Mar 08 '23 | Buy | 1.18 | 1,000,000 | 1,175,384 | 199,831,694 | Mar 09 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Nov 22 '22 | Buy | 1.49 | 300,000 | 446,673 | 198,831,694 | Nov 23 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Nov 09 '22 | Buy | 1.60 | 200,000 | 319,425 | 198,531,694 | Nov 10 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Oct 27 '22 | Buy | 1.82 | 100,000 | 182,007 | 198,331,694 | Oct 28 12:00 AM |
| OPK | FROST PHILLIP MD ET AL | CEO & Chairman | Oct 19 '22 | Buy | 1.72 | 100,000 | 172,070 | 198,231,694 | Oct 20 12:00 AM |