| GPCR | FMR LLC | 10 percent owner, other: See Remark 1 | Jul 22 '26 | Sale | 0.00 | 17,452 | 0 | 1,369 | Jul 24 |
| BEAM | FMR LLC | 10 percent owner, other: See Remark 1 | Jun 26 '26 | Sale | 35.26 | 251,488 | 8,867,467 | 854,583 | Jun 29 |
| BEAM | FMR LLC | 10 percent owner, other: See Remark 1 | Jun 25 '26 | Sale | 35.12 | 33,372 | 1,172,025 | 1,106,071 | Jun 29 |
| GPCR | FMR LLC | 10 percent owner, other: See Remark 1 | Apr 14 '26 | Sale | 0.00 | 17,452 | 0 | 2,736 | Apr 16 |
| GPCR | FMR LLC | 10 percent owner, other: See Remark 1 | Jan 15 '26 | Sale | 0.00 | 17,452 | 0 | 4,103 | Jan 20 |
| GPCR | FMR LLC | 10 percent owner, other: See Remark 1 | Dec 08 '25 | Sale | 0.00 | 52,356 | 0 | 0 | Dec 10 |
| BEAM | FMR LLC | 10 percent owner, other: See Remark 1 | Oct 27 '25 | Sale | 26.68 | 459 | 12,246 | 14 | Oct 29 |
| GPCR | FMR LLC | 10 percent owner, other: See Remark 1 | Jul 30 '25 | Sale | 0.00 | 26,310 | 0 | 1,515,558 | Aug 01 |
| BEAM | FMR LLC | 10 percent owner, other: See Remark 1 | Jul 30 '25 | Sale | 20.50 | 48,374 | 991,667 | 2,073,665 | Aug 01 |
| GPCR | FMR LLC | 10 percent owner, other: See Remark 1 | Feb 06 '25 | Sale | 0.00 | 41 | 0 | 0 | Feb 10 |
| SANA | FMR LLC | 10 percent owner, other: See Remark 1 | Jan 08 '25 | Sale | 6.49 | 290,912 | 1,887,320 | 4,541,511 | Jan 10 |
| GPCR | FMR LLC | 10 percent owner, other: See Remark 1 | Mar 14 '24 | Sale | 0.00 | 21,997 | 0 | 1,541,868 | Mar 18 |
| BEAM | FMR LLC | other: See Remark 1 | Feb 14 '24 | Sale | 30.55 | 900,000 | 27,496,912 | 1,235,511 | Feb 15 |
| BEAM | FMR LLC | other: See Remark 1 | Feb 13 '24 | Sale | 30.76 | 1,565 | 48,139 | 2,771,913 | Feb 15 |
| GPCR | FMR LLC | 10 percent owner, other: See Remark 1 | Feb 13 '24 | Sale | 0.00 | 525 | 0 | 1,563,865 | Feb 15 |
| GPCR | FMR LLC | 10% Owner | Dec 05 '23 | Sale | 0.00 | 17,454 | 0 | 2,733 | Dec 07 |
| GPCR | FMR LLC | 10% Owner | Oct 18 '23 | Sale | 0.00 | 17,454 | 0 | 4,101 | Oct 23 |
| BEAM | FMR LLC | director: | Sep 06 '22 | Sale | 54.25 | 551 | 29,892 | 0 | Sep 08 |
| BEAM | FMR LLC | 10 percent owner, other: See Remark 1 | Aug 05 '22 | Sale | 60.50 | 20,159 | 1,219,620 | 0 | Aug 08 |
| BEAM | FMR LLC | director: | Aug 04 '22 | Sale | 61.00 | 167 | 10,187 | 0 | Aug 08 |
| BEAM | FMR LLC | 10 percent owner, other: See Remark 1 | Apr 13 '22 | Sale | 50.39 | 18,803 | 947,557 | 0 | Apr 14 |
| BEAM | FMR LLC | director: | Apr 12 '22 | Sale | 50.75 | 663 | 33,647 | 0 | Apr 14 |
| COGT | FMR LLC | | Apr 03 '18 | Buy | 12.00 | 94,052 | 1,128,624 | 452,115 | Apr 05 |