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| Ticker | Owner | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| ORKA | Dambkowski Carl | Director | Jun 12 '26 | Sale | 70.11 | 12,583 | 882,182 | 38,743 | Jun 12 12:00 AM |
| ORKA | Dambkowski Carl | Director | Jun 11 '26 | Sale | 70.13 | 22,417 | 1,572,201 | 51,326 | Jun 12 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Jun 03 '26 | Option Exercise | 22.86 | 8,250 | 188,596 | 211,148 | Jun 05 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Jun 03 '26 | Sale | 78.71 | 5,500 | 432,905 | 205,648 | Jun 05 12:00 AM |
| ORKA | Dambkowski Carl | Director | May 21 '26 | Option Exercise | 7.95 | 124,520 | 989,610 | 178,743 | May 22 12:00 AM |
| ORKA | Dambkowski Carl | Director | May 21 '26 | Sale | 58.97 | 105,000 | 6,191,366 | 73,743 | May 22 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | May 06 '26 | Option Exercise | 22.86 | 8,250 | 188,596 | 212,523 | May 08 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | May 06 '26 | Sale | 84.14 | 5,500 | 462,784 | 207,023 | May 08 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Apr 01 '26 | Option Exercise | 22.86 | 8,250 | 188,596 | 213,898 | Apr 03 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Apr 01 '26 | Sale | 84.84 | 5,500 | 466,619 | 208,398 | Apr 03 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Mar 04 '26 | Option Exercise | 22.86 | 8,250 | 188,596 | 215,273 | Mar 06 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Mar 04 '26 | Sale | 71.06 | 5,500 | 390,825 | 209,773 | Mar 06 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Feb 04 '26 | Option Exercise | 22.86 | 8,250 | 188,596 | 216,648 | Feb 04 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Feb 04 '26 | Sale | 65.79 | 5,500 | 361,860 | 211,148 | Feb 04 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Jan 07 '26 | Sale | 77.84 | 18,700 | 1,455,613 | 212,523 | Jan 09 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Jan 07 '26 | Option Exercise | 22.86 | 28,050 | 641,224 | 231,223 | Jan 09 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Dec 04 '25 | Sale | 75.00 | 10,900 | 817,500 | 271,108 | Dec 05 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Nov 05 '25 | Sale | 55.07 | 10,785 | 593,903 | 282,008 | Nov 07 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Nov 05 '25 | Option Exercise | 22.86 | 16,120 | 368,504 | 292,793 | Nov 07 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Oct 01 '25 | Option Exercise | 22.86 | 4,770 | 109,042 | 289,843 | Oct 03 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Oct 01 '25 | Sale | 39.80 | 5,110 | 203,378 | 284,733 | Oct 03 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Sep 03 '25 | Sale | 37.87 | 2,725 | 103,198 | 233,548 | Sep 05 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Aug 06 '25 | Sale | 37.78 | 2,725 | 102,951 | 236,273 | Aug 08 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Jul 02 '25 | Sale | 45.09 | 10,090 | 454,954 | 238,998 | Jul 03 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Jul 02 '25 | Option Exercise | 22.86 | 14,730 | 336,728 | 249,088 | Jul 03 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Jun 04 '25 | Sale | 36.96 | 2,725 | 100,716 | 241,723 | Jun 06 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | May 07 '25 | Sale | 35.75 | 2,725 | 97,419 | 244,448 | May 09 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Apr 02 '25 | Sale | 36.22 | 3,860 | 139,802 | 247,173 | Apr 04 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Mar 05 '25 | Sale | 30.48 | 1,590 | 48,463 | 251,033 | Mar 07 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Feb 05 '25 | Option Exercise | 22.86 | 1,590 | 36,348 | 256,143 | Feb 07 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Feb 05 '25 | Sale | 40.69 | 3,520 | 143,229 | 252,623 | Feb 07 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Jan 02 '25 | Sale | 46.94 | 4,085 | 191,740 | 255,348 | Jan 03 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Jan 02 '25 | Option Exercise | 22.86 | 2,720 | 62,180 | 259,433 | Jan 03 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Dec 11 '24 | Sale | 48.76 | 4,540 | 221,363 | 258,073 | Dec 13 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Dec 11 '24 | Option Exercise | 22.86 | 3,630 | 82,982 | 262,613 | Dec 13 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Dec 04 '24 | Sale | 46.07 | 6,665 | 307,057 | 260,798 | Dec 06 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Nov 06 '24 | Sale | 59.12 | 6,665 | 394,041 | 267,463 | Nov 08 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Oct 02 '24 | Sale | 56.26 | 6,665 | 374,954 | 274,128 | Oct 04 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Sep 04 '24 | Sale | 47.56 | 6,665 | 316,969 | 280,793 | Sep 06 12:00 AM |
| APGE | Dambkowski Carl | Chief Medical Officer | Aug 07 '24 | Sale | 40.67 | 7,335 | 298,336 | 287,458 | Aug 09 12:00 AM |