| Ticker | Owner | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jun 23 '26 | Option Exercise | 0.00 | 3,040 | 0 | 383,342 | Jun 24 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Mar 23 '26 | Option Exercise | 0.00 | 5,635 | 0 | 392,520 | Mar 24 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Dec 23 '25 | Option Exercise | 0.00 | 5,635 | 0 | 376,640 | Dec 23 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Oct 30 '25 | Option Exercise | 22.40 | 23,500 | 526,400 | 378,005 | Oct 30 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Sep 23 '25 | Option Exercise | 0.00 | 5,636 | 0 | 356,724 | Sep 24 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Sep 18 '25 | Option Exercise | 32.29 | 54,075 | 1,746,113 | 351,088 | Sep 19 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Sep 16 '25 | Sale | 187.63 | 4,096 | 768,514 | 297,013 | Sep 16 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Sep 15 '25 | Sale | 181.93 | 5,000 | 909,647 | 301,109 | Sep 16 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Sep 09 '25 | Sale | 194.88 | 5,000 | 974,422 | 336,109 | Sep 09 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Sep 08 '25 | Sale | 192.30 | 5,000 | 961,511 | 341,109 | Sep 09 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Sep 03 '25 | Sale | 189.50 | 5,000 | 947,478 | 346,109 | Sep 03 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Sep 02 '25 | Sale | 180.64 | 5,000 | 903,180 | 351,109 | Sep 03 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Aug 29 '25 | Sale | 189.02 | 5,000 | 945,110 | 356,109 | Aug 29 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Aug 28 '25 | Sale | 187.79 | 5,000 | 938,969 | 361,109 | Aug 29 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jun 23 '25 | Option Exercise | 0.00 | 5,633 | 0 | 368,327 | Jun 24 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Apr 12 '25 | Option Exercise | 0.00 | 3,125 | 0 | 363,924 | Apr 14 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Mar 23 '25 | Option Exercise | 0.00 | 11,086 | 0 | 365,162 | Mar 25 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Feb 21 '25 | Sale | 98.78 | 8,334 | 823,240 | 354,076 | Feb 24 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Feb 10 '25 | Option Exercise | 22.40 | 10,000 | 224,000 | 343,856 | Feb 12 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jan 13 '25 | Sale | 141.02 | 841 | 118,599 | 333,856 | Jan 14 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jan 12 '25 | Option Exercise | 0.00 | 3,125 | 0 | 334,697 | Jan 14 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Dec 24 '24 | Sale | 146.22 | 1,504 | 219,912 | 331,572 | Dec 26 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Dec 23 '24 | Option Exercise | 0.00 | 3,818 | 0 | 333,076 | Dec 26 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Nov 07 '24 | Sale | 198.87 | 12,590 | 2,503,744 | 329,258 | Nov 08 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Nov 07 '24 | Option Exercise | 33.77 | 25,000 | 844,250 | 341,848 | Nov 08 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Nov 06 '24 | Sale | 204.17 | 12,590 | 2,570,516 | 351,848 | Nov 08 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Nov 06 '24 | Option Exercise | 33.77 | 25,000 | 844,250 | 364,438 | Nov 08 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Oct 30 '24 | Sale | 195.51 | 526 | 102,839 | 294,438 | Oct 31 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Oct 30 '24 | Option Exercise | 22.40 | 526 | 11,782 | 294,964 | Oct 31 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Oct 29 '24 | Sale | 201.51 | 34,474 | 6,946,979 | 294,438 | Oct 31 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Oct 29 '24 | Option Exercise | 22.40 | 34,474 | 772,218 | 328,912 | Oct 31 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Oct 14 '24 | Sale | 237.82 | 1,219 | 289,901 | 294,438 | Oct 15 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Oct 14 '24 | Option Exercise | 0.00 | 3,125 | 0 | 6,250 | Oct 15 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Oct 12 '24 | Option Exercise | 0.00 | 3,125 | 0 | 295,657 | Oct 15 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Sep 24 '24 | Sale | 209.12 | 1,498 | 313,257 | 292,532 | Sep 25 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Sep 23 '24 | Option Exercise | 0.00 | 3,818 | 0 | 294,030 | Sep 25 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jul 15 '24 | Sale | 175.43 | 1,187 | 208,234 | 291,412 | Jul 16 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jul 12 '24 | Option Exercise | 0.00 | 3,125 | 0 | 292,599 | Jul 16 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jul 08 '24 | Option Exercise | 22.40 | 5,000 | 112,000 | 294,474 | Jul 09 |
| PI | DIORIO CHRIS PH.D. | CHIEF EXECUTIVE OFFICER | Jul 08 '24 | Sale | 161.66 | 1,497 | 242,013 | 292,977 | Jul 09 |