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| Ticker | Owner | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| AGIO | Burns James William | Chief Legal Officer | Apr 02 '26 | Option Exercise | 0.00 | 17,000 | 0 | 52,586 | Apr 06 12:00 AM |
| AGIO | Burns James William | Chief Legal Officer | Apr 02 '26 | Sale | 34.71 | 3,280 | 113,849 | 49,306 | Apr 06 12:00 AM |
| AGIO | Burns James William | Chief Legal Officer | Mar 02 '26 | Option Exercise | 0.00 | 35,172 | 0 | 45,249 | Mar 03 12:00 AM |
| AGIO | Burns James William | Chief Legal Officer | Mar 02 '26 | Sale | 28.96 | 5,218 | 151,114 | 34,531 | Mar 03 12:00 AM |
| AGIO | Burns James William | Chief Legal Officer | Dec 30 '25 | Option Exercise | 0.00 | 12,000 | 0 | 34,650 | Jan 02 12:00 AM |
| AGIO | Burns James William | Chief Legal Officer | Dec 30 '25 | Sale | 27.09 | 2,932 | 79,428 | 31,718 | Jan 02 12:00 AM |
| AGIO | Burns James William | Chief Legal Officer | Jun 24 '25 | Option Exercise | 0.00 | 12,000 | 0 | 31,449 | Jun 26 12:00 AM |
| AGIO | Burns James William | Chief Legal Officer | Jun 24 '25 | Sale | 33.54 | 2,799 | 93,878 | 28,650 | Jun 26 12:00 AM |
| AGIO | Burns James William | Chief Legal Officer | Mar 03 '25 | Sale | 35.54 | 4,005 | 142,338 | 18,650 | Mar 04 12:00 AM |
| AGIO | Burns James William | Chief Legal Officer | Mar 01 '25 | Option Exercise | 0.00 | 27,000 | 0 | 27,130 | Mar 04 12:00 AM |
| AGIO | Burns James William | Chief Legal Officer | Nov 07 '24 | Sale | 52.21 | 21,752 | 1,135,775 | 15,700 | Nov 12 12:00 AM |
| AGIO | Burns James William | Chief Legal Officer | Mar 05 '24 | Sale | 32.57 | 2,642 | 86,050 | 34,518 | Mar 05 12:00 AM |
| AGIO | Burns James William | Chief Legal Officer | Mar 01 '24 | Option Exercise | 0.00 | 15,668 | 0 | 38,518 | Mar 05 12:00 AM |
| AGIO | Burns James William | Chief Legal Officer | Feb 14 '24 | Sale | 25.14 | 545 | 13,701 | 31,666 | Feb 14 12:00 AM |
| AGIO | Burns James William | Chief Legal Officer | Feb 12 '24 | Option Exercise | 0.00 | 3,666 | 0 | 32,211 | Feb 14 12:00 AM |
| AGIO | Burns James William | Chief Legal Officer | Jan 24 '24 | Sale | 21.64 | 1,708 | 36,961 | 30,378 | Jan 24 12:00 AM |
| AGIO | Burns James William | Chief Legal Officer | Jan 20 '24 | Option Exercise | 0.00 | 11,500 | 0 | 32,086 | Jan 24 12:00 AM |
| AGIO | Burns James William | Chief Legal Officer | Jan 09 '24 | Sale | 22.99 | 1,163 | 26,737 | 26,336 | Jan 09 12:00 AM |
| AGIO | Burns James William | Chief Legal Officer | Jan 05 '24 | Option Exercise | 0.00 | 6,500 | 0 | 27,499 | Jan 09 12:00 AM |
| AGIO | Burns James William | Chief Legal Officer | Aug 17 '23 | Sale | 26.28 | 6,395 | 168,061 | 23,890 | Aug 21 12:00 AM |
| AGIO | Burns James William | Chief Legal Officer | Jun 30 '23 | Sale | 28.36 | 1,707 | 48,411 | 30,285 | Jun 30 12:00 AM |
| AGIO | Burns James William | Chief Legal Officer | Jun 28 '23 | Option Exercise | 0.00 | 11,500 | 0 | 31,992 | Jun 30 12:00 AM |