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| Ticker | Owner | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| ACAD | Brege Laura | Director | May 29 '26 | Option Exercise | 0.00 | 8,107 | 0 | 23,202 | Jun 01 |
| MIRM | Brege Laura | Director | Sep 11 '25 | Option Exercise | 15.00 | 17,000 | 255,000 | 32,703 | Sep 12 |
| MIRM | Brege Laura | Director | Sep 11 '25 | Sale | 74.40 | 17,000 | 1,264,868 | 15,703 | Sep 12 |
| ACAD | Brege Laura | Director | Jun 04 '25 | Sale | 21.78 | 14,446 | 314,634 | 15,095 | Jun 05 |
| ACAD | Brege Laura | Director | May 29 '25 | Option Exercise | 0.00 | 9,387 | 0 | 29,541 | Jun 02 |
| MIRM | Brege Laura | Director | May 29 '25 | Option Exercise | 0.00 | 5,703 | 0 | 15,703 | Jun 02 |
| PCRX | Brege Laura | Director | Aug 16 '24 | Buy | 12.81 | 1,000 | 12,810 | 17,552 | Aug 19 |
| ACAD | Brege Laura | Director | May 29 '24 | Option Exercise | 0.00 | 6,652 | 0 | 20,154 | May 31 |
| ACAD | Brege Laura | Director | Jun 12 '23 | Sale | 24.87 | 4,500 | 111,906 | 13,502 | Jun 14 |
| PCRX | Brege Laura | Director | Jun 05 '23 | Sale | 38.74 | 600 | 23,244 | 9,547 | Jun 07 |
| ACAD | Brege Laura | Director | Jun 01 '23 | Option Exercise | 0.00 | 8,552 | 0 | 18,002 | Jun 05 |
| ACAD | Brege Laura | Director | Jun 07 '22 | Option Exercise | 0.00 | 6,391 | 0 | 9,450 | Jun 05 |
| ACAD | Brege Laura | Director | Jun 22 '21 | Option Exercise | 0.00 | 3,059 | 0 | 3,059 | Jun 05 |
| PCRX | Brege Laura | Director | Apr 03 '23 | Sale | 40.72 | 7,000 | 285,040 | 10,147 | Apr 05 |
| PCRX | Brege Laura | Director | Apr 03 '23 | Option Exercise | 29.90 | 7,000 | 209,300 | 17,147 | Apr 05 |
| ACAD | Brege Laura | Director | Jan 12 '23 | Sale | 18.25 | 12,500 | 228,125 | 0 | Jan 17 |
| ACAD | Brege Laura | Director | Jan 12 '23 | Option Exercise | 17.01 | 12,500 | 212,625 | 12,500 | Jan 17 |