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| Ticker | Owner | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Jun 26 '26 | Option Exercise | 49.19 | 5,635 | 277,180 | 10,304 | Jun 30 |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Jun 26 '26 | Sale | 80.16 | 5,635 | 451,699 | 4,669 | Jun 30 |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Apr 28 '26 | Sale | 71.79 | 1,626 | 116,727 | 44,909 | Apr 30 |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Apr 16 '26 | Sale | 74.56 | 5,619 | 418,953 | 46,535 | Apr 17 |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Apr 15 '26 | Option Exercise | 0.00 | 10,837 | 0 | 52,154 | Apr 17 |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Mar 04 '26 | Option Exercise | 45.71 | 439 | 20,067 | 4,585 | Mar 05 |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Mar 04 '26 | Sale | 80.00 | 201 | 16,080 | 4,347 | Mar 05 |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Mar 03 '26 | Sale | 79.72 | 6,220 | 495,867 | 4,347 | Mar 05 |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Mar 03 '26 | Option Exercise | 44.27 | 1,699 | 75,215 | 6,471 | Mar 05 |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Jan 30 '26 | Sale | 82.96 | 5,296 | 439,364 | 45,413 | Feb 02 |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Jan 16 '26 | Sale | 75.75 | 8,056 | 610,276 | 4,772 | Jan 20 |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Jan 15 '26 | Option Exercise | 0.00 | 19,887 | 0 | 47,338 | Jan 20 |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Oct 06 '25 | Sale | 69.37 | 1,625 | 112,725 | 30,301 | Oct 08 |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Oct 02 '25 | Option Exercise | 31.80 | 15,000 | 477,000 | 46,926 | Oct 02 |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Oct 02 '25 | Sale | 68.01 | 15,000 | 1,020,210 | 31,926 | Oct 02 |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Sep 09 '25 | Option Exercise | 31.80 | 11,950 | 380,010 | 43,876 | Sep 11 |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Sep 09 '25 | Sale | 62.16 | 11,950 | 742,838 | 31,926 | Sep 11 |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Sep 05 '25 | Option Exercise | 31.80 | 250 | 7,950 | 32,176 | Sep 09 |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Sep 05 '25 | Sale | 62.00 | 250 | 15,500 | 31,926 | Sep 09 |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Sep 03 '25 | Option Exercise | 31.80 | 32,800 | 1,043,040 | 46,926 | Sep 04 |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Sep 03 '25 | Sale | 59.34 | 32,800 | 1,946,220 | 16,926 | Sep 04 |