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| Ticker | Owner | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Apr 28 '26 | Sale | 71.79 | 1,626 | 116,727 | 44,909 | Apr 30 12:00 AM |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Apr 16 '26 | Sale | 74.56 | 5,619 | 418,953 | 46,535 | Apr 17 12:00 AM |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Apr 15 '26 | Option Exercise | 0.00 | 21,674 | 0 | 52,154 | Apr 17 12:00 AM |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Mar 04 '26 | Option Exercise | 45.71 | 878 | 40,134 | 4,585 | Mar 05 12:00 AM |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Mar 04 '26 | Sale | 80.00 | 201 | 16,080 | 4,347 | Mar 05 12:00 AM |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Mar 03 '26 | Option Exercise | 44.27 | 3,398 | 150,430 | 6,471 | Mar 05 12:00 AM |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Mar 03 '26 | Sale | 79.72 | 6,220 | 495,867 | 4,347 | Mar 05 12:00 AM |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Jan 30 '26 | Sale | 82.96 | 5,296 | 439,364 | 45,413 | Feb 02 12:00 AM |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Jan 16 '26 | Sale | 75.75 | 8,056 | 610,276 | 4,772 | Jan 20 12:00 AM |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Jan 15 '26 | Option Exercise | 0.00 | 39,774 | 0 | 49,474 | Jan 20 12:00 AM |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Oct 06 '25 | Sale | 69.37 | 1,625 | 112,725 | 30,301 | Oct 08 12:00 AM |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Oct 02 '25 | Option Exercise | 31.80 | 30,000 | 954,000 | 46,926 | Oct 02 12:00 AM |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Oct 02 '25 | Sale | 68.01 | 15,000 | 1,020,210 | 31,926 | Oct 02 12:00 AM |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Sep 09 '25 | Option Exercise | 31.80 | 23,900 | 760,020 | 43,876 | Sep 11 12:00 AM |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Sep 09 '25 | Sale | 62.16 | 11,950 | 742,838 | 31,926 | Sep 11 12:00 AM |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Sep 05 '25 | Option Exercise | 31.80 | 500 | 15,900 | 53,650 | Sep 09 12:00 AM |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Sep 05 '25 | Sale | 62.00 | 250 | 15,500 | 31,926 | Sep 09 12:00 AM |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Sep 03 '25 | Option Exercise | 31.80 | 65,600 | 2,086,080 | 83,900 | Sep 04 12:00 AM |
| IONS | Baroldi Joseph | EVP, Chief Business Officer | Sep 03 '25 | Sale | 59.34 | 32,800 | 1,946,220 | 16,926 | Sep 04 12:00 AM |